methyl (4-(2-(1,1-bis(4-fluorophenyl)ethylthio)ethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

Base Information

Chemical Name:methyl (4-(2-(1,1-bis(4-fluorophenyl)ethylthio)ethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate
CAS No.:258532-31-9
Molecular Formula:C₂₇H₂₇F₂NO₄S
Molecular Weight:499.578
Hs Code.:

Synonyms:methyl (4-(2-(1,1-bis(4-fluorophenyl)ethylthio)ethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

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Chemical Property of methyl (4-(2-(1,1-bis(4-fluorophenyl)ethylthio)ethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

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Technology Process of methyl (4-(2-(1,1-bis(4-fluorophenyl)ethylthio)ethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

There total 7 articles about methyl (4-(2-(1,1-bis(4-fluorophenyl)ethylthio)ethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1,1-bis-(4-fluorophenyl)ethanethiol

: 258533-13-0
methyl (4-(2-hydroxyethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

: 258532-31-9
methyl (4-(2-(1,1-bis(4-fluorophenyl)ethylthio)ethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

Guidance literature:

Reference yield:

: 258532-76-2
8-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine

: 258532-31-9
methyl (4-(2-(1,1-bis(4-fluorophenyl)ethylthio)ethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / pyridinium p-toluenesulfonate / dimethylformamide / 18 h / 20 °C

2: sodium hydride / dimethylformamide / 17.5 h / 20 °C

3: 7.01 g / BH₃-THF complex / tetrahydrofuran / 2 h / 20 °C

4: 97 percent / pyridinium p-toluenesulfonate / methanol / 1.5 h / 20 °C

5: 74 percent / potassium carbonate / dimethylformamide / 5.5 h / 20 °C

6: 311 mg / NaH / dimethylformamide / 20 °C

With borane-THF; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.050

Reference yield:

: 2-chloro-N-(2,3-dihydroxy-phenyl)-acetamide

: 258532-31-9
methyl (4-(2-(1,1-bis(4-fluorophenyl)ethylthio)ethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 922 mg / potassium carbonate / dimethylformamide / 2.5 h

2: 80 percent / pyridinium p-toluenesulfonate / dimethylformamide / 18 h / 20 °C

3: sodium hydride / dimethylformamide / 17.5 h / 20 °C

4: 7.01 g / BH₃-THF complex / tetrahydrofuran / 2 h / 20 °C

5: 97 percent / pyridinium p-toluenesulfonate / methanol / 1.5 h / 20 °C

6: 74 percent / potassium carbonate / dimethylformamide / 5.5 h / 20 °C

7: 311 mg / NaH / dimethylformamide / 20 °C

With borane-THF; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.050