{(S)-6-[(R)-7-fluoro-4-phenoxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

Base Information

Chemical Name:{(S)-6-[(R)-7-fluoro-4-phenoxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester
CAS No.:1610884-33-7
Molecular Formula:C₂₆H₂₃FO₅
Molecular Weight:434.464
Hs Code.:

Synonyms:{(S)-6-[(R)-7-fluoro-4-phenoxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

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Chemical Property of {(S)-6-[(R)-7-fluoro-4-phenoxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

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Technology Process of {(S)-6-[(R)-7-fluoro-4-phenoxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

There total 9 articles about {(S)-6-[(R)-7-fluoro-4-phenoxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610884-31-5
{(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

: 98-80-6
phenylboronic acid

: 1610884-33-7
{(S)-6-[(R)-7-fluoro-4-phenoxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

Guidance literature:: With oxygen; copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 16h; under 750.075 Torr;

Reference yield:

: 1458652-59-9
methyl 2-((S)-6-((R)-7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

: 1610884-33-7
{(S)-6-[(R)-7-fluoro-4-phenoxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; dihydrogen peroxide / water / 2.5 h / 20 °C / Cooling with ice

2: triethylamine; oxygen; copper diacetate / dichloromethane / 16 h / 20 °C / 750.08 Torr

With dihydrogen peroxide; oxygen; copper diacetate; acetic acid; triethylamine; In dichloromethane; water;

Reference yield:

: 1458652-58-8
methyl 2-((S)-6-((R)-4-bromo-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

: 1610884-33-7
{(S)-6-[(R)-7-fluoro-4-phenoxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere; Microwave irradiation

2: acetic acid; dihydrogen peroxide / water / 2.5 h / 20 °C / Cooling with ice

3: triethylamine; oxygen; copper diacetate / dichloromethane / 16 h / 20 °C / 750.08 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dihydrogen peroxide; oxygen; potassium acetate; copper diacetate; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane; water;