(R)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide

Base Information

Chemical Name:(R)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide
CAS No.:1199828-62-0
Molecular Formula:C₂₁H₁₉ClF₃N₃O₃S
Molecular Weight:485.914
Hs Code.:

Synonyms:(R)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide

There total 9 articles about (R)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.5%

: 1199827-85-4
(R)-(1-((2-amino-2,3-dihydro-1H-inden-5-yl)methyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol

: 2905-23-9
2-chlorophenylsulfonyl chloride

: 1199828-62-0
(R)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 321352-52-7
5-bromo-2-aminoindane hydrobromide

: 1199828-62-0
(R)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: 4-methyl-morpholine / methanol / 4 h / 20 - 65 °C

2: potassium carbonate / water; ethyl acetate / 20 °C / Cooling with ice bath

3: 1,8-diazabicyclo[5.4.0]undec-7-ene; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl / 0.5 h / 150 °C / Irradiation with microwave

4: lithium borohydride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere of nitrogen

5: thionyl chloride / dichloromethane / 0.75 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

7: hydrogenchloride; hydrogen / 20% palladium hydroxide-activated charcoal / ethanol; water / 0.58 h / 1500.15 Torr

8: triethylamine / tetrahydrofuran / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium borohydride; thionyl chloride; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1199827-78-5
(R)-methyl 2-(benzyloxycarbonylamino)-2,3-dihydro-1H-indene-5-carboxylate

: 1199828-62-0
(R)-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-yl)-2-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium borohydride / tetrahydrofuran; methanol / 20 °C / Inert atmosphere of nitrogen

2: thionyl chloride / dichloromethane / 0.75 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

4: hydrogenchloride; hydrogen / 20% palladium hydroxide-activated charcoal / ethanol; water / 0.58 h / 1500.15 Torr

5: triethylamine / tetrahydrofuran / 20 °C

With hydrogenchloride; lithium borohydride; thionyl chloride; hydrogen; potassium carbonate; triethylamine; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;