2-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-8-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-cyclooctanone

Base Information

• Chemical Name: 2-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-8-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-cyclooctanone
• CAS No.: 77109-80-9
• Molecular Formula: C₂₆H₃₂N₂O
• Molecular Weight: 388.553
• Mol file: 77109-80-9.mol

Synonyms:2-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-8-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-cyclooctanone

Chemical Property of 2-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-8-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-cyclooctanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-8-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-cyclooctanone

There total 1 articles about 2-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-8-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-cyclooctanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

cycloactanone (502-49-8) + 4-dimethylamino-benzaldehyde (100-10-7) → 2-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-8-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-cyclooctanone (77109-80-9)

Guidance literature:

With piperidine; pyridine; for 4h; Heating;

DOI:10.1021/je00024a037

Reference yield: 79.0%

2-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-8-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-cyclooctanone (77109-80-9) + thiourea (17356-08-0) → 4-(4-Dimethylamino-phenyl)-10-[1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione (77109-64-9)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1021/je00024a037

Reference yield:

2-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-8-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-cyclooctanone (77109-80-9) → 4-(4-Dimethylamino-phenyl)-10-[1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one (77109-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / KOH / ethanol / 3 h / Heating

2: 65 percent / NaOAc / acetic acid; acetic anhydride / 2.5 h / Heating

With potassium hydroxide; sodium acetate; In ethanol; acetic anhydride; acetic acid;

DOI:10.1021/je00024a037

upstream raw materials:

cycloactanone

4-dimethylamino-benzaldehyde

Downstream raw materials:

4-(4-Dimethylamino-phenyl)-10-[1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-3,4,5,6,7,8,9,10-octahydro-1H-cyclooctapyrimidine-2-thione

4-(4-Dimethylamino-phenyl)-10-[1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-5,6,7,8,9,10-hexahydro-4H-1-thia-3a,11-diaza-cycloocta[f]inden-3-one