(R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,5-dimethyloxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

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Chemical Name:(R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,5-dimethyloxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide
CAS No.:1616100-71-0
Molecular Formula:C₂₃H₂₆F₂N₄O₃S
Molecular Weight:476.547
Hs Code.:

Synonyms:(R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,5-dimethyloxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,5-dimethyloxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,5-dimethyloxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

There total 9 articles about (R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,5-dimethyloxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.9%

: 23000-12-6
1-(2,5-dimethyloxazol-4-yl)ethanone

: 1585971-39-6
(R,E)-N-(1-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1616100-71-0
(R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,5-dimethyloxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: 1-(2,5-dimethyloxazol-4-yl)ethanone; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 1h;

(R,E)-N-(1-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)ethylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield:

: 940879-48-1
1-(2,5-dimethyloxazol-4-yl)ethanol

: 1616100-71-0
(R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,5-dimethyloxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / chloroform / 12 h / 75 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 °C

With manganese(IV) oxide; potassium hexamethylsilazane; In tetrahydrofuran; chloroform;

Reference yield:

: 92901-88-7
2,5-Dimethyl-4-oxazolecarboxaldehyde

: 1616100-71-0
(R)-N-((S)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(2,5-dimethyloxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl ether / 1 h / 20 °C

2.1: manganese(IV) oxide / chloroform / 12 h / 75 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

3.2: 2 h / -78 °C

With manganese(IV) oxide; potassium hexamethylsilazane; In tetrahydrofuran; diethyl ether; chloroform;