3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-indazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride

Base Information

• Chemical Name: 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-indazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride
• CAS No.: 1034474-20-8
• Molecular Formula: C₂₁H₁₃Cl₂N₇O*ClH
• Molecular Weight: 486.747

Synonyms:3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-indazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride

Chemical Property of 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-indazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-indazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride

There total 13 articles about 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-indazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-indazol-4-yl}oxy)-5-chlorobenzonitrile (1034474-35-5) → 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-indazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride (1034474-20-8)

Guidance literature:

With hydrogenchloride; In methanol; chloroform; water; Inert atmosphere;

DOI:10.1021/jm2010173

Reference yield:

3-bromo-5-chlorophenyl 2-chloro-5-fluorophenyl ether (1034474-29-7) → 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-indazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride (1034474-20-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane; ethylbenzene / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: hydrazine hydrate / ethanol / 96 h / 95 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 90 °C / Inert atmosphere

4.1: lithium tert-butoxide / N,N-dimethyl-formamide / Inert atmosphere

4.2: 25 °C / Cooling with ice; Inert atmosphere

5.1: trifluoroacetic acid / 2 h / 75 °C / Inert atmosphere

6.1: hydrogenchloride / methanol; chloroform; water / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrazine hydrate; trifluoroacetic acid; lithium tert-butoxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; hexane; chloroform; ethylbenzene; water; N,N-dimethyl-formamide;

DOI:10.1021/jm2010173

Reference yield:

2-(3-bromo-5-chlorophenoxy)-3-chloro-6-fluorobenzaldehyde (1034474-30-0) → 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-indazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride (1034474-20-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrazine hydrate / ethanol / 96 h / 95 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 90 °C / Inert atmosphere

3.1: lithium tert-butoxide / N,N-dimethyl-formamide / Inert atmosphere

3.2: 25 °C / Cooling with ice; Inert atmosphere

4.1: trifluoroacetic acid / 2 h / 75 °C / Inert atmosphere

5.1: hydrogenchloride / methanol; chloroform; water / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrazine hydrate; trifluoroacetic acid; lithium tert-butoxide; In methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1021/jm2010173

upstream raw materials:

3-({1-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methyl]-5-chloro-1H-indazol-4-yl}oxy)-5-chlorobenzonitrile

tert-butyl 1-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-1H-pyrazolo[3,4-b]pyridine-3-carboxylate

3-chloro-5-{[5-chloro-1-({1-(4-methoxybenzyl)-6-[(4-methoxybenzyl)amino]-1H-pyrazolo[3,4-b]pyridin-3-yl}methyl)-1H-indazol-4-yl]oxy}benzonitrile

3-bromo-5-chlorophenyl 2-chloro-5-fluorophenyl ether

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1034474-20-8 3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-indazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-6-aminium chloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send