N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine

Base Information

Chemical Name:N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine
CAS No.:1191279-73-8
Molecular Formula:C₂₅H₂₂N₄O₄
Molecular Weight:442.474
Hs Code.:

Synonyms:N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine

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Chemical Property of N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine

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Technology Process of N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine

There total 1 articles about N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1191279-71-6
N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-iodo)phenoxy-3-nitropyridin-2-amine

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1191279-73-8
N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 7h; Inert atmosphere;
DOI:10.1016/j.bmcl.2009.07.080

Reference yield: 69.0%

: 1191279-73-8
N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine

N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine: 1191279-74-9
N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxy-3-nitropyridin-2-amine

Guidance literature:: With sodium hydroxide; In toluene; for 16h; Reflux;
DOI:10.1016/j.bmcl.2009.07.080

Reference yield:

: 1191279-73-8
N-(4'-cyanophenyl)-6-[2'',6''-dimethyl-4''-(3-methylbut-3-ol-1-yn)-phenoxy]-3-nitropyridin-2-amine

N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine: 1191279-81-8
N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-ethynyl)phenoxypyridin-2,3-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / toluene / 24 h / Inert atmosphere; Reflux

2: sodium dithionite; ammonia / tetrahydrofuran; water / 2 h / 20 °C

With sodium dithionite; ammonia; sodium hydroxide; In tetrahydrofuran; water; toluene;