[(1R,2S)-1-Benzyl-2-hydroxy-2-(3-methyl-butylthiocarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(1R,2S)-1-Benzyl-2-hydroxy-2-(3-methyl-butylthiocarbamoyl)-ethyl]-carbamic acid tert-butyl ester
• CAS No.: 114886-79-2
• Molecular Formula: C₂₀H₃₂N₂O₃S
• Molecular Weight: 380.552

Synonyms:[(1R,2S)-1-Benzyl-2-hydroxy-2-(3-methyl-butylthiocarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Chemical Property of [(1R,2S)-1-Benzyl-2-hydroxy-2-(3-methyl-butylthiocarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of [(1R,2S)-1-Benzyl-2-hydroxy-2-(3-methyl-butylthiocarbamoyl)-ethyl]-carbamic acid tert-butyl ester

There total 3 articles about [(1R,2S)-1-Benzyl-2-hydroxy-2-(3-methyl-butylthiocarbamoyl)-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Acetic acid (1S,2R)-2-tert-butoxycarbonylamino-1-(3-methyl-butylthiocarbamoyl)-3-phenyl-propyl ester (114886-78-1) → [(1R,2S)-1-Benzyl-2-hydroxy-2-(3-methyl-butylthiocarbamoyl)-ethyl]-carbamic acid tert-butyl ester (114886-79-2)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/jm00119a022

Reference yield:

Acetic acid (1S,2R)-2-tert-butoxycarbonylamino-1-(3-methyl-butylcarbamoyl)-3-phenyl-propyl ester (114886-77-0) → [(1R,2S)-1-Benzyl-2-hydroxy-2-(3-methyl-butylthiocarbamoyl)-ethyl]-carbamic acid tert-butyl ester (114886-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / Lawesson's reagent / benzene / 2 h / Heating

2: 81 percent / aq. NaOH

With Lawessons reagent; sodium hydroxide; In benzene;

DOI:10.1021/jm00119a022

Reference yield:

[(1R,2R)-1-Benzyl-2-hydroxy-2-(3-methyl-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester → [(1R,2S)-1-Benzyl-2-hydroxy-2-(3-methyl-butylthiocarbamoyl)-ethyl]-carbamic acid tert-butyl ester (114886-79-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / N-methylmorpholine, DMAP / ethyl acetate

2: 46 percent / Lawesson's reagent / benzene / 2 h / Heating

3: 81 percent / aq. NaOH

With Lawessons reagent; 4-methyl-morpholine; dmap; sodium hydroxide; In ethyl acetate; benzene;

DOI:10.1021/jm00119a022

upstream raw materials:

Acetic acid (1S,2R)-2-tert-butoxycarbonylamino-1-(3-methyl-butylthiocarbamoyl)-3-phenyl-propyl ester

Acetic acid (1S,2R)-2-tert-butoxycarbonylamino-1-(3-methyl-butylcarbamoyl)-3-phenyl-propyl ester

Downstream raw materials:

(2S,3R)-3-Amino-2-hydroxy-N-(3-methyl-butyl)-4-phenyl-thiobutyramide; hydrochloride

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