5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl]amino}thiophene-3-carboxamide

Base Information

Chemical Name:5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl]amino}thiophene-3-carboxamide
CAS No.:1201924-05-1
Molecular Formula:C₂₃H₂₂F₂N₄O₄S
Molecular Weight:488.515
Hs Code.:

5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl]amino}thiophene-3-carboxamide

Synonyms:5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl]amino}thiophene-3-carboxamide

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Chemical Property of 5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl]amino}thiophene-3-carboxamide

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Technology Process of 5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl]amino}thiophene-3-carboxamide

There total 7 articles about 5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl]amino}thiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093878-16-0
2-amino-5-(2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl)thiophene-3-carboxamide

: 1201924-06-2
2-chloro-6-(2-hydroxyethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

: 1201924-05-1
5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl]amino}thiophene-3-carboxamide

Guidance literature:: With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tert-Amyl alcohol; at 100 ℃; Inert atmosphere;

Reference yield:

: 461-96-1
3,5-difluorobromobenzene

: 1201924-05-1
5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl]amino}thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / -78 - -75 °C

1.2: 2 h

2.1: potassium tert-butylate / tetrahydrofuran / Inert atmosphere; Cooling with ice

2.2: 6 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / hexanes; tert-butyl methyl ether / 1 h / -78 °C

3.2: -78 °C

4.1: hydrogenchloride; water / acetone / 20 °C / Cooling with ice

5.1: sulfur; triethylamine / N,N-dimethyl-formamide / 20 °C / Cooling with ice

6.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-Amyl alcohol / 100 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; potassium tert-butylate; water; potassium carbonate; sulfur; triethylamine; diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; hexanes; tert-Amyl alcohol; tert-butyl methyl ether; N,N-dimethyl-formamide; acetone;

Reference yield:

: 537013-51-7
4-bromo-2,6-difluorobenzaldehyde

: 1201924-05-1
5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxyethyl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl]amino}thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / Inert atmosphere; Cooling with ice

1.2: 6 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / hexanes; tert-butyl methyl ether / 1 h / -78 °C

2.2: -78 °C

3.1: hydrogenchloride; water / acetone / 20 °C / Cooling with ice

4.1: sulfur; triethylamine / N,N-dimethyl-formamide / 20 °C / Cooling with ice

5.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-Amyl alcohol / 100 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; potassium tert-butylate; water; potassium carbonate; sulfur; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; hexanes; tert-Amyl alcohol; tert-butyl methyl ether; N,N-dimethyl-formamide; acetone;