6-bromo-3-isopropoxy-2-methoxybenzyl bromide

Base Information

• Chemical Name: 6-bromo-3-isopropoxy-2-methoxybenzyl bromide
• CAS No.: 610788-38-0
• Molecular Formula: C₁₁H₁₄Br₂O₂
• Molecular Weight: 338.039
• Mol file: 610788-38-0.mol

Synonyms:6-bromo-3-isopropoxy-2-methoxybenzyl bromide

Chemical Property of 6-bromo-3-isopropoxy-2-methoxybenzyl bromide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 6-bromo-3-isopropoxy-2-methoxybenzyl bromide

There total 1 articles about 6-bromo-3-isopropoxy-2-methoxybenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

3-isopropoxy-2-methoxybenzylalcohol → 6-bromo-3-isopropoxy-2-methoxybenzyl bromide (610788-38-0)

Guidance literature:

With bromine; In chloroform; at 20 ℃; for 3h;

DOI:10.1055/s-2004-822371

Reference yield: 71.0%

N-methyl-6,7-(methylenedioxy)-1-naphthylamine (219781-97-2) + 6-bromo-3-isopropoxy-2-methoxybenzyl bromide (610788-38-0) → N-(6-bromo-3-isopropoxy-2-methoxybenzyl)-N-methyl-6,7-methylenedioxy-1-naphthylamine (610788-39-1)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1055/s-2003-39911 DOI:10.1055/s-2004-822371

Reference yield:

6-bromo-3-isopropoxy-2-methoxybenzyl bromide (610788-38-0) → N-(3-isopropoxy-2-methoxybenzyl)-N-methyl-6,7-methylenedioxy-1-naphthylamine

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / K₂CO₃; Bu₄NI / dimethylformamide / 100 °C

2: 56 percent / P(o-tol)3; KOH / Pd(OAc)2 / dimethylformamide / 4 h / Heating

With potassium hydroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; tris-(o-tolyl)phosphine; palladium diacetate; In N,N-dimethyl-formamide;

DOI:10.1055/s-2004-822371

Downstream raw materials:

N-(6-bromo-3-isopropoxy-2-methoxybenzyl)-N-methyl-6,7-methylenedioxy-1-naphthylamine