C₂₅H₂₄FN₃O₂

Base Information

• Chemical Name: C₂₅H₂₄FN₃O₂
• CAS No.: 1260493-33-1
• Molecular Formula: C₂₅H₂₄FN₃O₂
• Molecular Weight: 417.483
• Mol file: 1260493-33-1.mol

Synonyms:C₂₅H₂₄FN₃O₂

Chemical Property of C₂₅H₂₄FN₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₄FN₃O₂

There total 11 articles about C₂₅H₂₄FN₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tent-butyl 8-(4-(4-fluorobenzyloxy)-2-oxopyridin-1(2H)-yl)-6-methyl-3,4,5,6-tetrahydroazepino[4, 3-b]indole-2 (1H)-carboxylate (1260494-71-0) → C25H24FN3O2 (1260493-33-1)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃;

Reference yield:

4-fluorobenzylic alcohol (459-56-3) → C25H24FN3O2 (1260493-33-1)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate; 1,10-Phenanthroline / copper(l) iodide / toluene / 105 °C

2: formic acid; ammonium acetate / water / 144 h / Reflux

3: caesium carbonate; 8-quinolinol / copper(l) iodide / dimethyl sulfoxide / 135 °C / Inert atmosphere

4: hydrogenchloride / dichloromethane; diethyl ether / 20 °C

With hydrogenchloride; 8-quinolinol; formic acid; 1,10-Phenanthroline; ammonium acetate; caesium carbonate; copper(l) iodide; In diethyl ether; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

3-bromophenylhydrazine hydrochloride (27246-81-7) → C25H24FN3O2 (1260493-33-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: hydrogenchloride / ethanol; water / 1 h / Reflux

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; tetrahydrofuran / 0.75 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C

4.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 20 h / Reflux

5.1: diphenyl phosphoryl azide / 4.5 h / 100 °C

5.2: Sonication

5.3: pH 7

6.1: borane-THF / tetrahydrofuran / 21 h / Reflux

6.2: 4.5 h / Reflux

7.1: caesium carbonate; 8-quinolinol / copper(l) iodide / dimethyl sulfoxide / 135 °C / Inert atmosphere

8.1: hydrogenchloride / dichloromethane; diethyl ether / 20 °C

With hydrogenchloride; 8-quinolinol; borane-THF; diphenyl phosphoryl azide; hydroxylamine hydrochloride; sodium acetate; sodium hydride; caesium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; copper(l) iodide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

tent-butyl 8-(4-(4-fluorobenzyloxy)-2-oxopyridin-1(2H)-yl)-6-methyl-3,4,5,6-tetrahydroazepino[4, 3-b]indole-2 (1H)-carboxylate

4-fluorobenzylic alcohol

3-bromophenylhydrazine hydrochloride

cyclohexanone

Downstream raw materials:

4-(4-Fluorobenzyloxy)-1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indol-8-yl)pyridin-2(1H)-one hydrochloride

Refernces