N-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)-2-fluoroisonicotinamide

Base Information

Chemical Name:N-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)-2-fluoroisonicotinamide
CAS No.:1615725-38-6
Molecular Formula:C₂₄H₁₇F₄N₇O
Molecular Weight:495.439
Hs Code.:

Synonyms:N-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)-2-fluoroisonicotinamide

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Chemical Property of N-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)-2-fluoroisonicotinamide

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Technology Process of N-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)-2-fluoroisonicotinamide

There total 7 articles about N-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)-2-fluoroisonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 430-67-1
2,2-difluorethylamine

: 1293396-43-6
N-((4-fluorophenyl)(tosyl)methyl)acetamide

: 1615730-45-4
2-fluoro-N-(6-formylimidazo[1,2-b]pyridazin-2-yl)isonicotinamide

: 1615725-38-6
N-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)-2-fluoroisonicotinamide

Guidance literature:: N-((4-fluorophenyl)(tosyl)methyl)acetamide; 2-fluoro-N-(6-formylimidazo[1,2-b]pyridazin-2-yl)isonicotinamide; With 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 20 - 40 ℃;

2,2-difluorethylamine; With acetic acid; In ethanol; at 90 - 105 ℃;

Reference yield:

: 1615730-39-6
N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-fluoroisonicotinamide

: 1615725-38-6
N-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)-2-fluoroisonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C / 7757.43 Torr / Autoclave

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 3.5 h / 20 °C / Cooling

3.1: Dess-Martin periodane / dimethyl sulfoxide / 1 h

4.1: triethylamine; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide / dichloromethane; 1-methyl-pyrrolidin-2-one / 20 - 40 °C

4.2: 90 - 105 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 887625-09-4
6-chloroimidazo[1,2-b]pyridazine-2-amine

: 1615725-38-6
N-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-methyl-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)-2-fluoroisonicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4.5 h / 20 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 100 °C / 7757.43 Torr / Autoclave

3.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 3.5 h / 20 °C / Cooling

4.1: Dess-Martin periodane / dimethyl sulfoxide / 1 h

5.1: triethylamine; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide / dichloromethane; 1-methyl-pyrrolidin-2-one / 20 - 40 °C

5.2: 90 - 105 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;