2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1S,2R)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

Base Information

Chemical Name:2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1S,2R)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid
CAS No.:1374119-20-6
Molecular Formula:C₃₅H₄₅NO₁₀
Molecular Weight:639.743
Hs Code.:

Synonyms:2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1S,2R)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

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Chemical Property of 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1S,2R)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

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Technology Process of 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1S,2R)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

There total 14 articles about 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1S,2R)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-(2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

: 1374119-20-6
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1S,2R)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

: 1374119-21-7
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1R,2S)-2-ethyl-1-hydroxycyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: methanol; water; trifluoroacetic acid / Resolution of racemate

With trifluoroacetic acid; In methanol; dichloromethane; water; trifluoroacetic acid;
DOI:10.1021/jm201746x

Reference yield:

: 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1RS,2SR)-2-ethyl-1-hydroxycyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

: 1374119-20-6
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1S,2R)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

: 1374119-21-7
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1R,2S)-2-ethyl-1-hydroxycyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

Guidance literature:: In methanol; water; trifluoroacetic acid; Resolution of racemate;
DOI:10.1021/jm201746x

Reference yield:

: rac-(1S,2R)-2-ethyl-1-((trimethylsilyl)ethynyl)cyclohexanol

: 1374119-20-6
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1S,2R)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

: 1374119-21-7
2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1R,2S)-2-ethyl-1-hydroxycyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; silver nitrate / acetone / 2 h / 20 °C / Darkness

2.1: potassium permanganate; sodium hydrogencarbonate; magnesium sulfate / water / 0 - 20 °C

3.1: lithium hydroxide / methanol; water / 6 h / 20 °C

3.2: pH 2

4.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 16 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: methanol; water; trifluoroacetic acid / Resolution of racemate

With potassium permanganate; N-Bromosuccinimide; sodium hydrogencarbonate; magnesium sulfate; silver nitrate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane; water; acetone; acetonitrile; trifluoroacetic acid;
DOI:10.1021/jm201746x