(E)-3-Dimethylamino-1-(3-methyl-thiophen-2-yl)-2-(2-nitro-phenyl)-propenone

Base Information

• Chemical Name: (E)-3-Dimethylamino-1-(3-methyl-thiophen-2-yl)-2-(2-nitro-phenyl)-propenone
• CAS No.: 157068-42-3
• Molecular Formula: C₁₆H₁₆N₂O₃S
• Molecular Weight: 316.381
• Mol file: 157068-42-3.mol

Synonyms:(E)-3-Dimethylamino-1-(3-methyl-thiophen-2-yl)-2-(2-nitro-phenyl)-propenone

Chemical Property of (E)-3-Dimethylamino-1-(3-methyl-thiophen-2-yl)-2-(2-nitro-phenyl)-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-Dimethylamino-1-(3-methyl-thiophen-2-yl)-2-(2-nitro-phenyl)-propenone

There total 1 articles about (E)-3-Dimethylamino-1-(3-methyl-thiophen-2-yl)-2-(2-nitro-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methylthenoyl chloride (61341-26-2) + 1-methyl-2-nitrobenzene (88-72-2) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → (E)-3-Dimethylamino-1-(3-methyl-thiophen-2-yl)-2-(2-nitro-phenyl)-propenone (157068-42-3)

Guidance literature:

With triethylamine; Yield given. Multistep reaction; 1.) DMF;

DOI:10.1021/jm00045a004

Reference yield: 67.0%

(E)-3-Dimethylamino-1-(3-methyl-thiophen-2-yl)-2-(2-nitro-phenyl)-propenone (157068-42-3) → 2-(2-Nitrophenyl)-1-(3-methyl-thien-2-yl)ethanone (157068-45-6)

Guidance literature:

With water; In 1,4-dioxane; Heating;

DOI:10.1021/jm00045a004

Reference yield:

(E)-3-Dimethylamino-1-(3-methyl-thiophen-2-yl)-2-(2-nitro-phenyl)-propenone (157068-42-3) → 2-Amino-α-(3-methyl-2-thienyl)benzeneethanamine dihydrochloride

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / H₂O / dioxane / Heating

2: 1.) NH₂OH, 2.) Ac₂O, pyridine, 3.) BH₃/THF

3: Fe/HCl

With tetrahydrofuran; pyridine; hydrogenchloride; borane; water; hydroxylamine; acetic anhydride; iron; In 1,4-dioxane;

DOI:10.1021/jm00045a004

upstream raw materials:

3-methylthenoyl chloride

1-methyl-2-nitrobenzene

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

2-(2-Nitrophenyl)-1-(3-methyl-thien-2-yl)ethanone

2-nitro-α-(3-methyl-thien-2-yl)benzeneethanamine