(2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol

Base Information

Chemical Name:(2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol
CAS No.:529494-90-4
Molecular Formula:C₃₉H₇₄O₇Si₂
Molecular Weight:711.183
Hs Code.:

(2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol

Synonyms:(2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol

Suppliers and Price of (2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol

There total 20 articles about (2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 529494-89-1
(4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-1-{(2S,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octan-2-one

: 529494-90-4
(2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol

Guidance literature:: With acetic acid; tetramethylammonium triacetoxyborohydride; In acetonitrile; at -40 - -20 ℃; for 24h;
DOI:10.1002/anie.200390112

Reference yield: 99.0%

: (S)-8-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-1-{(2S,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octan-2-one

: 529494-90-4
(2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol

Guidance literature:: With tetramethylammonium triacetoxyborohydride; In acetic acid; acetonitrile; at -35 - -15 ℃; for 30h;
DOI:10.1016/S0040-4020(03)00814-7

Reference yield:

: 193416-33-0
Triethyl-[(E)-5-(4-methoxy-benzyloxy)-1-methylene-pent-2-enyloxy]-silane

: 529494-90-4
(2R,4R,5S)-8-(tert-Butyl-dimethyl-silanyloxy)-1-{(2R,4R,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-4-triisopropylsilanyloxy-tetrahydro-pyran-2-yl}-5-methyl-octane-2,4-diol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 4 Angstroem molecular sieves / (1S,2R)-1-amino-2-indanol-derived tridentate Cr catalyst / 12 h / 20 °C

1.2: 80 percent / conc. HCl / CHCl₃ / 4 h

2.1: 93 percent / NaBH₄ / methanol / 1 h / 20 °C

3.1: 93 percent / 2,6-lutidine / CH₂Cl₂ / 3 h / -78 °C

4.1: 88 percent / 10-camphorsulfonic acid / CH₂Cl₂; methanol / 1 h / 20 °C

5.1: pyridine / CH₂Cl₂ / 1 h / -10 °C

6.1: LDA; HMPA / tetrahydrofuran; hexane / 0.25 h / -78 °C

6.2: tetrahydrofuran; hexane / -78 - 20 °C

7.1: 85 mg / K₂CO₃ / methanol / 12 h / 20 °C

8.1: 86 percent / pyridinium p-toluenesulfonate; Hg(OAc)2; H₂O / tetrahydrofuran / 1.5 h / 45 °C

9.1: Et₃N; c-Hex₂BCl / diethyl ether / 0.5 h / 0 °C

9.2: 99 percent / diethyl ether / 20 h / -78 - -30 °C

10.1: 99 percent / Me₄NBH(OAc)3 / acetonitrile; acetic acid / 30 h / -35 - -15 °C

With pyridine; 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; 4 A molecular sieve; (1S)-10-camphorsulfonic acid; dicyclohexylboron chloride; mercury(II) diacetate; water; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; tetramethylammonium triacetoxyborohydride; lithium diisopropyl amide; (1S,2R)-1-amino-2-indanol-derived tridentate Cr catalyst; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; acetic acid; acetonitrile; 1.1: hetero-Diels-Alder reaction / 10.1: Evans-Saksena reduction;
DOI:10.1016/S0040-4020(03)00814-7