pseudo-β-yohimbine

Base Information

Chemical Name:pseudo-β-yohimbine
CAS No.:549-82-6
Molecular Formula:C₂₁H₂₆N₂O₃
Molecular Weight:354.449
Hs Code.:

Synonyms:pseudo-β-yohimbine

Suppliers and Price of pseudo-β-yohimbine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of pseudo-β-yohimbine

Chemical Property:

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Technology Process of pseudo-β-yohimbine

There total 35 articles about pseudo-β-yohimbine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.9%

: 2114-90-1,2671-55-8,2671-57-0,18210-73-6,24204-01-1,40088-11-7,41904-77-2,59952-51-1,67711-33-5,83540-87-8,89015-76-9,114030-03-4
methyl (16α)-17-oxoyohimban-16-carboxylate

: 84-37-7,131-03-3,146-48-5,483-09-0,483-10-3,522-92-9,522-94-1,549-82-6,549-84-8,2516-78-1,6835-85-4,24252-70-8,25920-66-5,40085-29-8,40085-30-1,40085-32-3,40088-19-5,40088-20-8,40088-25-3,41787-60-4,41904-78-3,59904-75-5,59952-52-2,59952-53-3,59952-56-6,83540-86-7,83540-88-9,103834-06-6,103834-07-7
(+/-)-β-yohimbine

: 84-37-7,131-03-3,146-48-5,483-09-0,483-10-3,522-92-9,522-94-1,549-82-6,549-84-8,2516-78-1,6835-85-4,24252-70-8,25920-66-5,40085-29-8,40085-30-1,40085-32-3,40088-19-5,40088-20-8,40088-25-3,41787-60-4,41904-78-3,59904-75-5,59952-52-2,59952-53-3,59952-56-6,83540-86-7,83540-88-9,103834-06-6,103834-07-7
3α-15α-20β-17α-hydroxylyohimbine-16α-carboxylic acid methyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.333333h;
DOI:10.1021/jo00008a025

Reference yield: 52.9%

: 2114-90-1,2671-55-8,2671-57-0,18210-73-6,24204-01-1,40088-11-7,41904-77-2,59952-51-1,67711-33-5,83540-87-8,89015-76-9,114030-03-4
methyl (16α)-17-oxoyohimban-16-carboxylate

: 84-37-7,131-03-3,146-48-5,483-09-0,483-10-3,522-92-9,522-94-1,549-82-6,549-84-8,2516-78-1,6835-85-4,24252-70-8,25920-66-5,40085-29-8,40085-30-1,40085-32-3,40088-19-5,40088-20-8,40088-25-3,41787-60-4,41904-78-3,59904-75-5,59952-52-2,59952-53-3,59952-56-6,83540-86-7,83540-88-9,103834-06-6,103834-07-7
(+/-)-β-yohimbine

: 84-37-7,131-03-3,146-48-5,483-09-0,483-10-3,522-92-9,522-94-1,549-82-6,549-84-8,2516-78-1,6835-85-4,24252-70-8,25920-66-5,40085-29-8,40085-30-1,40085-32-3,40088-19-5,40088-20-8,40088-25-3,41787-60-4,41904-78-3,59904-75-5,59952-52-2,59952-53-3,59952-56-6,83540-86-7,83540-88-9,103834-06-6,103834-07-7
3α-15α-20β-17α-hydroxylyohimbine-16α-carboxylic acid methyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.333333h;
DOI:10.1021/jo00008a025

Reference yield:

: 61-54-1
tryptamine

: 84-37-7,131-03-3,146-48-5,483-09-0,483-10-3,522-92-9,522-94-1,549-82-6,549-84-8,2516-78-1,6835-85-4,24252-70-8,25920-66-5,40085-29-8,40085-30-1,40085-32-3,40088-19-5,40088-20-8,40088-25-3,41787-60-4,41904-78-3,59904-75-5,59952-52-2,59952-53-3,59952-56-6,83540-86-7,83540-88-9,103834-06-6,103834-07-7
3α-15α-20β-17α-hydroxylyohimbine-16α-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / potassium carbonate / ethanol; H₂O / 0.5 h / Heating

2: 1) m-(chloroperoxy)benzoic acid, 2) triethylamine, acetic anhydride / 1) diethyl ether/dichloromethane, 0 to 20 deg C, 2 h, 2) CH₂Cl₂, 0 deg C, 30 min

3: 95 percent / CH₂Cl₂ / 0.5 h / 20 °C

4: 1) 1,4-diazabicyclo<5.4.0>undec-7-ene (DBU) / 1) N,N-dimethylacetamide, 2) a) 20 deg C, 1h, b) 70 deg C, 1h

5: 50 percent / 50percent aq. sulfuric acid / methanol / 24 h / 20 °C

6: 65.6 percent / conc. hydrochloric acid, H₂ / 10percent Pd-C / methanol / 18 h / 20 °C / 760 Torr

7: 22.2 percent / sodium borohydride / methanol / 0.33 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; 1,4-diazabicyclo[5.4.0]-7-undecene; sulfuric acid; hydrogen; acetic anhydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jo00008a025