<4(S)-<<-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

Base Information

Chemical Name:<4(S)-<<-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine
CAS No.:97920-12-2
Molecular Formula:C₄₀H₅₆F₂N₈O₇
Molecular Weight:798.931
Hs Code.:

<4(S)-<<<N-(tert-butyloxycarbonyl)-L-phenylalanyl>-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

Synonyms:<4(S)-<<-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

Suppliers and Price of <4(S)-<<-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of <4(S)-<<-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of <4(S)-<<-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

There total 21 articles about <4(S)-<<-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 97920-10-0
<4(S)-<<-N^im-tosyl-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

: 97920-12-2
<4(S)-<<-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

Guidance literature:: With benzotriazol-1-ol; In methanol; for 14h; Ambient temperature;
DOI:10.1021/jm00160a048

Reference yield:

: 82010-31-9
(S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester

: 97920-12-2
<4(S)-<<-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / oxalyl chloride, Et₃N / CH₂Cl₂ / -78 °C

2: 60 percent / Zn / tetrahydrofuran / 0.5 h / Heating

3: 1 M aq. NaOH / tetrahydrofuran / 2 h

4: 74 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 48 h

5: CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

6: Et₃N, diethylphosphoryl cyanide / CH₂Cl₂ / 15 h

7: CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

8: Et₃N, diethylphosphoryl cyanide / CH₂Cl₂

9: 70 percent / 1-hydroxybenzotriazole / methanol / 14 h / Ambient temperature

With sodium hydroxide; diethylphosphoryl cyanide; oxalyl dichloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00160a048