3-(3-aminophenyl)-N-n-propylpiperidine

Base Information

• Chemical Name: 3-(3-aminophenyl)-N-n-propylpiperidine
• CAS No.: 79601-43-7
• Molecular Formula: C₁₄H₂₂N₂
• Molecular Weight: 218.342
• Mol file: 79601-43-7.mol

Synonyms:3-(3-aminophenyl)-N-n-propylpiperidine

Chemical Property of 3-(3-aminophenyl)-N-n-propylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-aminophenyl)-N-n-propylpiperidine

There total 13 articles about 3-(3-aminophenyl)-N-n-propylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) → 3-(3-aminophenyl)-N-n-propylpiperidine (79601-43-7)

Guidance literature:

Multi-step reaction with 12 steps

1: dichlorobis(triphenylphosphine)nickel(II) / tetrahydrofuran / 24 h / Ambient temperature

2: KMnO₄ / H₂O / Heating

3: HCl / 24 h / Heating

4: H₂, conc. HCl / PtO₂ / methanol / 2585.7 Torr

5: 4.8 g / Et₃N / diethyl ether / 1 h

6: NaOH / methanol; H₂O / 4 h

7: Et₃N / acetone / 1.5 h / -10 °C

8: NaN₃ / acetone; H₂O / 1 h / -10 °C

9: toluene / Heating

10: 3.0 g / 24 h / Heating

11: 1.1 g / H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

12: LiAlH₄ / tetrahydrofuran / 3 h

With hydrogenchloride; sodium hydroxide; potassium permanganate; bis(triphenylphosphine)nickel(II) chloride; lithium aluminium tetrahydride; sodium azide; hydrogen; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water; acetone; toluene;

DOI:10.1021/jm00144a021

Reference yield:

3-(3-methylphenyl)pyridine (4385-67-5) → 3-(3-aminophenyl)-N-n-propylpiperidine (79601-43-7)

Guidance literature:

Multi-step reaction with 11 steps

1: KMnO₄ / H₂O / Heating

2: HCl / 24 h / Heating

3: H₂, conc. HCl / PtO₂ / methanol / 2585.7 Torr

4: 4.8 g / Et₃N / diethyl ether / 1 h

5: NaOH / methanol; H₂O / 4 h

6: Et₃N / acetone / 1.5 h / -10 °C

7: NaN₃ / acetone; H₂O / 1 h / -10 °C

8: toluene / Heating

9: 3.0 g / 24 h / Heating

10: 1.1 g / H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

11: LiAlH₄ / tetrahydrofuran / 3 h

With hydrogenchloride; sodium hydroxide; potassium permanganate; lithium aluminium tetrahydride; sodium azide; hydrogen; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water; acetone; toluene;

DOI:10.1021/jm00144a021

Reference yield:

3-pyridin-3-yl-benzoic acid methyl ester (79601-27-7) → 3-(3-aminophenyl)-N-n-propylpiperidine (79601-43-7)

Guidance literature:

Multi-step reaction with 9 steps

1: H₂, conc. HCl / PtO₂ / methanol / 2585.7 Torr

2: 4.8 g / Et₃N / diethyl ether / 1 h

3: NaOH / methanol; H₂O / 4 h

4: Et₃N / acetone / 1.5 h / -10 °C

5: NaN₃ / acetone; H₂O / 1 h / -10 °C

6: toluene / Heating

7: 3.0 g / 24 h / Heating

8: 1.1 g / H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

9: LiAlH₄ / tetrahydrofuran / 3 h

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; hydrogen; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water; acetone; toluene;

DOI:10.1021/jm00144a021

upstream raw materials:

1-[3-(3-Amino-phenyl)-piperidin-1-yl]-propan-1-one

3-Bromopyridine

3-(3-methylphenyl)pyridine

3-pyridin-3-yl-benzoic acid methyl ester

Downstream raw materials:

N-n-Propyl-3-(3-hydroxyphenyl)piperidine hydrochloride

Refernces