(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid

Base Information

Chemical Name:(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid
CAS No.:1174039-19-0
Molecular Formula:C₂₃H₂₄F₆N₄O₅
Molecular Weight:550.458
Hs Code.:

(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid

Synonyms:(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid

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Chemical Property of (R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid

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Technology Process of (R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid

There total 16 articles about (R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1174039-18-9
(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid methyl ester

: 1174039-19-0
(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid

Guidance literature:: (R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid methyl ester; With water; sodium hydroxide; In methanol; for 1h;

With hydrogenchloride; In water; pH=3 - 5;

Reference yield:

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 1174039-19-0
(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.08 h

1.2: 2 h

2.1: N-Bromosuccinimide / ethanol / 1 h

2.2: 1 h

3.1: potassium carbonate / dicobalt octacarbonyl / methanol / 0.08 h

3.2: 2 h / 60 °C

4.1: sodium hydroxide; water / methanol / 1 h

4.2: pH 3 - 5

With N-Bromosuccinimide; water; potassium carbonate; triethylamine; sodium hydroxide; dicobalt octacarbonyl; In methanol; ethanol; dichloromethane;

Reference yield:

: 1152439-73-0
2,2-dimethyl-5-[2-(2,4,5-trifluorophenyl)acetyl]-[1,3]dioxane-4,6-dione

: 1174039-19-0
(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / ethanol / 12 h / 70 °C

2.1: ammonium acetate / methanol / 3 h / Reflux

3.1: hydrogen / chloro(1,5-cyclooctadiene)rhodium(I) dimer; (R)-1-[(S)-2-(diphenyl phosphino)ferrocenyl]-ethyl-tert-butylphosphine / water; methanol / 24 h / 30 °C / 5069.54 Torr

4.1: sodium hydroxide; water / methanol / 1.5 h / 40 - 45 °C

4.2: pH 2 - 3

5.1: triethylamine / dichloromethane / 0.08 h

5.2: 2 h

6.1: N-Bromosuccinimide / ethanol / 1 h

6.2: 1 h

7.1: potassium carbonate / dicobalt octacarbonyl / methanol / 0.08 h

7.2: 2 h / 60 °C

8.1: sodium hydroxide; water / methanol / 1 h

8.2: pH 3 - 5

With N-Bromosuccinimide; ethanol; ammonium acetate; water; hydrogen; potassium carbonate; triethylamine; sodium hydroxide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; dicobalt octacarbonyl; (R)-1-[(S)-2-(diphenyl phosphino)ferrocenyl]-ethyl-tert-butylphosphine; In methanol; ethanol; dichloromethane; water;