8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine

Base Information

Chemical Name:8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine
CAS No.:1354627-20-5
Molecular Formula:C₁₈H₂₂Cl₂N₄O₃SSi
Molecular Weight:473.455
Hs Code.:

Synonyms:8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine

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Chemical Property of 8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine

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Technology Process of 8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine

There total 5 articles about 8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1354627-01-2
8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-7H-purine

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1354627-20-5
8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine

Guidance literature:: 8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-7H-purine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1.5h;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.5h;

With water; In N,N-dimethyl-formamide; mineral oil; Cooling;

Reference yield:

: 50-30-6
2,6-dichlorobenzoic acid

: 1354627-20-5
8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine

Guidance literature:: Multi-step reaction with 5 steps

1.1: polyphosphoric acid / 4 h / 190 °C

1.2: 20 °C / pH 7 - 8 / Cooling with ice

2.1: phosphorus(V) oxybromide / acetonitrile / 0.67 h / 150 °C

3.1: N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4.1: Oxone / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 - 20 °C

5.2: 0.5 h / 0 - 20 °C

5.3: Cooling

With Oxone; sodium hydride; phosphorus(V) oxybromide; In N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1227958-56-6
6-bromo-8-(2,6-dichlorophenyl)-9H-purine

: 1354627-20-5
8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.1: Oxone / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 - 20 °C

3.2: 0.5 h / 0 - 20 °C

3.3: Cooling

With Oxone; sodium hydride; In N,N-dimethyl-formamide; mineral oil;