2-((carbobenzyloxyamino)methyl)-4-benzyl-5-(N-benzyltrifluoroacetamido)oxazole

Base Information

Chemical Name:2-((carbobenzyloxyamino)methyl)-4-benzyl-5-(N-benzyltrifluoroacetamido)oxazole
CAS No.:87784-04-1
Molecular Formula:C₂₈H₂₄F₃N₃O₄
Molecular Weight:523.511
Hs Code.:

Synonyms:2-((carbobenzyloxyamino)methyl)-4-benzyl-5-(N-benzyltrifluoroacetamido)oxazole

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Chemical Property of 2-((carbobenzyloxyamino)methyl)-4-benzyl-5-(N-benzyltrifluoroacetamido)oxazole

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Technology Process of 2-((carbobenzyloxyamino)methyl)-4-benzyl-5-(N-benzyltrifluoroacetamido)oxazole

There total 4 articles about 2-((carbobenzyloxyamino)methyl)-4-benzyl-5-(N-benzyltrifluoroacetamido)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 30189-49-2
L-carbobenzyloxyglycylphenylalanine N-benzylamide

: 407-25-0
trifluoroacetic anhydride

: 87784-04-1
2-((carbobenzyloxyamino)methyl)-4-benzyl-5-(N-benzyltrifluoroacetamido)oxazole

Guidance literature:: In dichloromethane; trifluoroacetic acid; for 8h; Ambient temperature;
DOI:10.1021/ja00364a041

Reference yield: 92.0%

: 354-38-1
2,2,2-trifluoroacetamide

: 30189-49-2
N-(N-benzyloxycarbonyl-glycyl)-phenylalanine benzylamide

: 87784-04-1
2-((carbobenzyloxyamino)methyl)-4-benzyl-5-(N-benzyltrifluoroacetamido)oxazole

Guidance literature:: trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4039(00)88384-7

Reference yield:

: 1170-76-9,5540-03-4,54885-66-4
L-carbobenzyloxyglycylphenylalanine

: 87784-04-1
2-((carbobenzyloxyamino)methyl)-4-benzyl-5-(N-benzyltrifluoroacetamido)oxazole

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 0.5 h / -5 °C

2: 177 mg / tetrahydrofuran / -5 deg C , 10 min; -> RT, 40 min

3: 92 percent / trifluoroacetic acid; CH₂Cl₂ / 8 h / Ambient temperature

With triethylamine; In tetrahydrofuran; dichloromethane; trifluoroacetic acid;
DOI:10.1021/ja00364a041