Diisopropyl-phosphoramidous acid (1R,2S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohexyl ester 2-cyano-ethyl ester

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Chemical Name:Diisopropyl-phosphoramidous acid (1R,2S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohexyl ester 2-cyano-ethyl ester
CAS No.:233266-21-2
Molecular Formula:C₄₈H₅₄N₇O₅P
Molecular Weight:839.974
Hs Code.:

Diisopropyl-phosphoramidous acid (1R,2S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohexyl ester 2-cyano-ethyl ester

Synonyms:Diisopropyl-phosphoramidous acid (1R,2S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohexyl ester 2-cyano-ethyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (1R,2S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohexyl ester 2-cyano-ethyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (1R,2S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohexyl ester 2-cyano-ethyl ester

There total 16 articles about Diisopropyl-phosphoramidous acid (1R,2S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohexyl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 233266-15-4
N⁶-Benzoyl-9-[(1S,3R,4S)-4-(monomethoxytrityl)oxymethyl-3-hydroxycyclohexanyl]adenine

: 233266-21-2
Diisopropyl-phosphoramidous acid (1R,2S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohexyl ester 2-cyano-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: (1S,2R,5R)-5-(6-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-2-trityloxymethyl-cyclohexanol

: 233266-21-2
Diisopropyl-phosphoramidous acid (1R,2S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohexyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 42 percent / DCC; DMAP / CH₂Cl₂ / 2 h / 0 - 20 °C

2: KOH / methanol / 0.5 h

3: AcOH; H₂O / 50 °C

4: pyridine / 1 h / 0 °C

5: pyridine / 2 h / 20 °C

6: NH₃; H₂O / methanol / 0.5 h

7: pyridine / 2 h / 20 °C

8: 79 percent / (iPr)2NEt / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; dmap; potassium hydroxide; ammonia; water; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; 1: Acylation / 2: deacylation / 3: detritylation / 4: Substitution / 5: Acylation / 6: desilylation / 7: Substitution / 8: Substitution;

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 233266-21-2
Diisopropyl-phosphoramidous acid (1R,2S,5S)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohexyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 2 h / 20 °C

2: 79 percent / (iPr)2NEt / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Substitution / 2: Substitution;