N-hydroxy-1-[3-(methylsulfanyl)phenyl]-1-(1-methyl-1H-tetrazol-5-yl)methanimine

Base Information

• Chemical Name: N-hydroxy-1-[3-(methylsulfanyl)phenyl]-1-(1-methyl-1H-tetrazol-5-yl)methanimine
• CAS No.: 1187836-98-1
• Molecular Formula: C₁₀H₁₁N₅OS
• Molecular Weight: 249.296
• Mol file: 1187836-98-1.mol

Synonyms:N-hydroxy-1-[3-(methylsulfanyl)phenyl]-1-(1-methyl-1H-tetrazol-5-yl)methanimine

Chemical Property of N-hydroxy-1-[3-(methylsulfanyl)phenyl]-1-(1-methyl-1H-tetrazol-5-yl)methanimine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-hydroxy-1-[3-(methylsulfanyl)phenyl]-1-(1-methyl-1H-tetrazol-5-yl)methanimine

There total 4 articles about N-hydroxy-1-[3-(methylsulfanyl)phenyl]-1-(1-methyl-1H-tetrazol-5-yl)methanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methanone (1187836-97-0) → N-hydroxy-1-[3-(methylsulfanyl)phenyl]-1-(1-methyl-1H-tetrazol-5-yl)methanimine (1187836-98-1)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; at 70 ℃; for 5h;

Reference yield:

3-methylsulfanyl-benzoic acid (825-99-0) → N-hydroxy-1-[3-(methylsulfanyl)phenyl]-1-(1-methyl-1H-tetrazol-5-yl)methanimine (1187836-98-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Chloro-oxo-acetic acid / N,N-dimethyl-formamide / 0 - 20 °C

2.1: triethylamine / 0 - 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0 °C

3.2: 5 - 20 °C

4.1: pyridine; hydroxylamine hydrochloride / 5 h / 70 °C

With pyridine; Chloro-oxo-acetic acid; hydroxylamine hydrochloride; isopropylmagnesium chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran;

Reference yield:

3-(methylsulfanyl)benzoyl chloride (770-04-7) → N-hydroxy-1-[3-(methylsulfanyl)phenyl]-1-(1-methyl-1H-tetrazol-5-yl)methanimine (1187836-98-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / 0 - 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0 °C

2.2: 5 - 20 °C

3.1: pyridine; hydroxylamine hydrochloride / 5 h / 70 °C

With pyridine; hydroxylamine hydrochloride; isopropylmagnesium chloride; triethylamine; In tetrahydrofuran;

upstream raw materials:

[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methanone

N-methoxy-N-methyl-3-(methylsulfanyl)benzamide

3-(methylsulfanyl)benzoyl chloride

3-methylsulfanyl-benzoic acid

Downstream raw materials:

4-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}-1,3-thiazol-2-amine

tert-butyl (2-cyclohexylethyl)(6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-yl)carbamate

N-[(2-bromo-1,3-thiazol-4-yl)methoxy]-1-[3-(methylsulfanyl)phenyl]-1-(1-methyl-1H-tetrazol-5-yl)methanimine

2-(6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-yl)-1H-isoindole-1,3(2H)-dione