(2S,6S)-N-[(1R,2R)-N-(2-hydroxy-1-methyl-2-phenyl)ethyl]-N,2,6-trimethyloctanamide

Base Information

Chemical Name:(2S,6S)-N-[(1R,2R)-N-(2-hydroxy-1-methyl-2-phenyl)ethyl]-N,2,6-trimethyloctanamide
CAS No.:333718-31-3
Molecular Formula:C₂₀H₃₃NO₂
Molecular Weight:319.488
Hs Code.:

Synonyms:(2S,6S)-N-[(1R,2R)-N-(2-hydroxy-1-methyl-2-phenyl)ethyl]-N,2,6-trimethyloctanamide

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Chemical Property of (2S,6S)-N-[(1R,2R)-N-(2-hydroxy-1-methyl-2-phenyl)ethyl]-N,2,6-trimethyloctanamide

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Technology Process of (2S,6S)-N-[(1R,2R)-N-(2-hydroxy-1-methyl-2-phenyl)ethyl]-N,2,6-trimethyloctanamide

There total 7 articles about (2S,6S)-N-[(1R,2R)-N-(2-hydroxy-1-methyl-2-phenyl)ethyl]-N,2,6-trimethyloctanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 333718-30-2
(S)-1-iodo-4-methylhexane

: 192060-67-6
(1R,2R)-(-)-pseudoephedrinepropionamide

: 333718-31-3
(2S,6S)-N-[(1R,2R)-N-(2-hydroxy-1-methyl-2-phenyl)ethyl]-N,2,6-trimethyloctanamide

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1002/1099-0690(200101)2001:2<353::aid-ejoc353>3.0.co;2-z

Reference yield:

: 1565-80-6
(2S)-2-methyl-1-butanol

: 333718-31-3
(2S,6S)-N-[(1R,2R)-N-(2-hydroxy-1-methyl-2-phenyl)ethyl]-N,2,6-trimethyloctanamide

Guidance literature:: Multi-step reaction with 7 steps

1: 57 percent / Br₂; PPh₃; imidazole / CH₂Cl₂

2: NaOEt / ethanol / Heating

3: KOH / methanol / Heating

4: 4 h / 190 °C

5: 86 percent / LiAlH₄ / diethyl ether

6: 82 percent / iodine; PPh₃; imidazole / CH₂Cl₂ / 5 h

7: 86 percent / LDA / hexane; tetrahydrofuran

With 1H-imidazole; potassium hydroxide; lithium aluminium tetrahydride; bromine; iodine; sodium ethanolate; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane;
DOI:10.1002/1099-0690(200101)2001:2<353::aid-ejoc353>3.0.co;2-z

Reference yield:

: 534-00-9
(S)-2-methylbutyl bromide

: 333718-31-3
(2S,6S)-N-[(1R,2R)-N-(2-hydroxy-1-methyl-2-phenyl)ethyl]-N,2,6-trimethyloctanamide

Guidance literature:: Multi-step reaction with 6 steps

1: NaOEt / ethanol / Heating

2: KOH / methanol / Heating

3: 4 h / 190 °C

4: 86 percent / LiAlH₄ / diethyl ether

5: 82 percent / iodine; PPh₃; imidazole / CH₂Cl₂ / 5 h

6: 86 percent / LDA / hexane; tetrahydrofuran

With 1H-imidazole; potassium hydroxide; lithium aluminium tetrahydride; iodine; sodium ethanolate; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane;
DOI:10.1002/1099-0690(200101)2001:2<353::aid-ejoc353>3.0.co;2-z