(4S,5S)-4-Cyclohexylmethyl-5-((R)-3-hydroxy-2-methyl-propyl)-oxazolidin-2-one

Base Information

Chemical Name:(4S,5S)-4-Cyclohexylmethyl-5-((R)-3-hydroxy-2-methyl-propyl)-oxazolidin-2-one
CAS No.:126027-83-6
Molecular Formula:C₁₄H₂₅NO₃
Molecular Weight:255.357
Hs Code.:

Synonyms:(4S,5S)-4-Cyclohexylmethyl-5-((R)-3-hydroxy-2-methyl-propyl)-oxazolidin-2-one

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Chemical Property of (4S,5S)-4-Cyclohexylmethyl-5-((R)-3-hydroxy-2-methyl-propyl)-oxazolidin-2-one

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Technology Process of (4S,5S)-4-Cyclohexylmethyl-5-((R)-3-hydroxy-2-methyl-propyl)-oxazolidin-2-one

There total 11 articles about (4S,5S)-4-Cyclohexylmethyl-5-((R)-3-hydroxy-2-methyl-propyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 126027-82-5
(4S,5S)-5-((R)-3-tert-Butoxy-2-methyl-propyl)-4-cyclohexylmethyl-oxazolidin-2-one

: 126027-83-6
(4S,5S)-4-Cyclohexylmethyl-5-((R)-3-hydroxy-2-methyl-propyl)-oxazolidin-2-one

Guidance literature:: With trimethylsilyl iodide; In dichloromethane; for 0.5h;
DOI:10.1016/S0040-4039(00)99090-7

Reference yield:

: 147426-13-9
(4S,5S)-4-Cyclohexylmethyl-5-((R)-2-phenyl-propyl)-oxazolidin-2-one

: 126027-83-6
(4S,5S)-4-Cyclohexylmethyl-5-((R)-3-hydroxy-2-methyl-propyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 10percent aq. NaIO₄, RuO₄ / ethyl acetate / Ambient temperature

2: sodium bis(2-methoxyethoxy)aluminum hydride

With sodium periodate; ruthenium tetroxide; sodium bis(2-methoxyethoxy)aluminium dihydride; In ethyl acetate;
DOI:10.1021/jo00060a052

Reference yield:

: (2R,4S,5S)-5-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-4-<(2',2',2'-trichloro-1',1'-dimethylethoxycarbonyl)oxy>hexanoic acid

: 126027-83-6
(4S,5S)-4-Cyclohexylmethyl-5-((R)-3-hydroxy-2-methyl-propyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: TFA / CH₂Cl₂

2: 0.3 M aq. NaOH

3: sodium bis(2-methoxyethoxy)aluminum hydride

With sodium hydroxide; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo00060a052