3-<1-methyl-4-(1-methyl-3-benzyloxycarbonylaminopyrazole-5-carboxamido)-pyrrole-2-carboxamido>propionitrile

Base Information

Chemical Name:3-<1-methyl-4-(1-methyl-3-benzyloxycarbonylaminopyrazole-5-carboxamido)-pyrrole-2-carboxamido>propionitrile
CAS No.:223437-61-4
Molecular Formula:C₂₂H₂₃N₇O₄
Molecular Weight:449.469
Hs Code.:

Synonyms:3-<1-methyl-4-(1-methyl-3-benzyloxycarbonylaminopyrazole-5-carboxamido)-pyrrole-2-carboxamido>propionitrile

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Chemical Property of 3-<1-methyl-4-(1-methyl-3-benzyloxycarbonylaminopyrazole-5-carboxamido)-pyrrole-2-carboxamido>propionitrile

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Technology Process of 3-<1-methyl-4-(1-methyl-3-benzyloxycarbonylaminopyrazole-5-carboxamido)-pyrrole-2-carboxamido>propionitrile

There total 1 articles about 3-<1-methyl-4-(1-methyl-3-benzyloxycarbonylaminopyrazole-5-carboxamido)-pyrrole-2-carboxamido>propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 97950-77-1
3-(1-methyl-4-aminopyrrole-2-carboxamido)propionitrile

: 117860-60-3
1-methyl-3-benzyloxy-carbonylamino-pyrazole-5-carboxylic acid

: 223437-61-4
3-<1-methyl-4-(1-methyl-3-benzyloxycarbonylaminopyrazole-5-carboxamido)-pyrrole-2-carboxamido>propionitrile

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1016/S0968-0896(98)00205-3

Reference yield:

: 223437-61-4
3-<1-methyl-4-(1-methyl-3-benzyloxycarbonylaminopyrazole-5-carboxamido)-pyrrole-2-carboxamido>propionitrile

: 5-[(4-{4-[bis-(2-chloro-ethyl)-amino]-benzoylamino}-1-methyl-1H-pyrrole-2-carbonyl)-amino]-2-methyl-2H-pyrazole-3-carboxylic acid [5-(2-carbamimidoyl-ethylcarbamoyl)-1-methyl-1H-pyrrol-3-yl]-amide; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / methanol; dioxane / 3 h / 2585.74 Torr

2: HOBt, EDC / dimethylformamide / 12 h / Ambient temperature

3: 1. ) HCl gas, 2.) NH₃ gas / 1.) EtOH, 0 deg C, 1 h; room temperature, 10 min, 2.) EtOH, room temperature, 24 h

4: H₂, aq. HCl / Pd/C / methanol; dioxane / 4 h / 2585.74 Torr

5: NaHCO₃ / dioxane; H₂O / 3 h / Ambient temperature

With hydrogenchloride; ammonia; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00205-3

Reference yield:

: 223437-61-4
3-<1-methyl-4-(1-methyl-3-benzyloxycarbonylaminopyrazole-5-carboxamido)-pyrrole-2-carboxamido>propionitrile

: C₃₀H₃₆Cl₂N₁₂O₄*ClH

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / methanol; dioxane / 3 h / 2585.74 Torr

2: HOBt, EDC / dimethylformamide / 12 h / Ambient temperature

3: 1. ) HCl gas, 2.) NH₃ gas / 1.) EtOH, 0 deg C, 1 h; room temperature, 10 min, 2.) EtOH, room temperature, 24 h

4: H₂, aq. HCl / Pd/C / methanol; dioxane / 4 h / 2585.74 Torr

5: NaHCO₃ / dioxane; H₂O / 3 h / Ambient temperature

With hydrogenchloride; ammonia; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00205-3