3-(4-methoxy-phenyl)-4-pyridin-3-yl-thieno[2,3-b]thiophene-2,5-dicarboxylic acid

Base Information

Chemical Name:3-(4-methoxy-phenyl)-4-pyridin-3-yl-thieno[2,3-b]thiophene-2,5-dicarboxylic acid
CAS No.:676540-71-9
Molecular Formula:C₂₀H₁₃NO₅S₂
Molecular Weight:411.459
Hs Code.:

3-(4-methoxy-phenyl)-4-pyridin-3-yl-thieno[2,3-<i>b</i>]thiophene-2,5-dicarboxylic acid

Synonyms:3-(4-methoxy-phenyl)-4-pyridin-3-yl-thieno[2,3-b]thiophene-2,5-dicarboxylic acid

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Chemical Property of 3-(4-methoxy-phenyl)-4-pyridin-3-yl-thieno[2,3-b]thiophene-2,5-dicarboxylic acid

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Technology Process of 3-(4-methoxy-phenyl)-4-pyridin-3-yl-thieno[2,3-b]thiophene-2,5-dicarboxylic acid

There total 4 articles about 3-(4-methoxy-phenyl)-4-pyridin-3-yl-thieno[2,3-b]thiophene-2,5-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 676540-70-8
3-(4-methoxyphenyl)-4-(3-pyridyl)thieno[2,3-b]thiophene-2,5-diethyl ester

: 676540-71-9
3-(4-methoxy-phenyl)-4-pyridin-3-yl-thieno[2,3-b]thiophene-2,5-dicarboxylic acid

Guidance literature:: With potassium hydroxide; In water; dimethyl sulfoxide; at 100 ℃; for 10h;
DOI:10.1016/j.molstruc.2003.10.026

Reference yield:

: 614-18-6
3-pyridinecarboxylic acid ethyl ester

: 676540-71-9
3-(4-methoxy-phenyl)-4-pyridin-3-yl-thieno[2,3-b]thiophene-2,5-dicarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 66 percent / NaH / dimethylformamide / 6 h / 0 - 20 °C

2.1: K₂CO₃; tetrabutylammonium bromide / dimethylformamide / 0.5 h / 20 °C

2.2: dimethylformamide / 24 h / 20 °C

3.1: 50 percent / NaOEt / ethanol / 0.5 h / 0 °C

4.1: 85 percent / KOH / dimethylsulfoxide; H₂O / 10 h / 100 °C

With potassium hydroxide; tetrabutylammomium bromide; sodium ethanolate; sodium hydride; potassium carbonate; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 3.1: Dieckman cyclization;
DOI:10.1016/j.molstruc.2003.10.026

Reference yield:

: 38187-42-7
1-(4-methoxyphenyl)-3-(3-pyridyl)propane-1,3-dione

: 676540-71-9
3-(4-methoxy-phenyl)-4-pyridin-3-yl-thieno[2,3-b]thiophene-2,5-dicarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃; tetrabutylammonium bromide / dimethylformamide / 0.5 h / 20 °C

1.2: dimethylformamide / 24 h / 20 °C

2.1: 50 percent / NaOEt / ethanol / 0.5 h / 0 °C

3.1: 85 percent / KOH / dimethylsulfoxide; H₂O / 10 h / 100 °C

With potassium hydroxide; tetrabutylammomium bromide; sodium ethanolate; potassium carbonate; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: Dieckman cyclization;
DOI:10.1016/j.molstruc.2003.10.026