(E)-3-[(3aR,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-phenyl-propenone

Base Information

Chemical Name:(E)-3-[(3aR,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-phenyl-propenone
CAS No.:175543-73-4
Molecular Formula:C₂₈H₂₆ClN₃O₅
Molecular Weight:519.985
Hs Code.:

Synonyms:(E)-3-[(3aR,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-phenyl-propenone

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Chemical Property of (E)-3-[(3aR,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-phenyl-propenone

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Technology Process of (E)-3-[(3aR,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-phenyl-propenone

There total 6 articles about (E)-3-[(3aR,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-phenyl-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 175543-73-4
(E)-3-[(3aR,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-phenyl-propenone

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Et₂NTMS, 2.) TMSOTf / 1.) dichloroethane, 80 deg C, 2 h, 2.) dichloroethane, 80 deg C

2: NH₃-CH₃OH / 72 h / 23 °C

3: p-TsOH / dimethylformamide

4: DMSO, DCC

5: tetrahydrofuran

With methanol; trimethylsilyl trifluoromethanesulfonate; ammonia; toluene-4-sulfonic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; N,N-diethyl-1,1,1-trimethylsilanamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(95)00574-D

Reference yield:

: 112446-99-8
4-chloro-6-methoxy-3-methyl-1H-pyrazolo<3,4-b>quinoline

: 175543-73-4
(E)-3-[(3aR,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-phenyl-propenone

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Et₂NTMS, 2.) TMSOTf / 1.) dichloroethane, 80 deg C, 2 h, 2.) dichloroethane, 80 deg C

2: NH₃-CH₃OH / 72 h / 23 °C

3: p-TsOH / dimethylformamide

4: DMSO, DCC

5: tetrahydrofuran

With methanol; trimethylsilyl trifluoromethanesulfonate; ammonia; toluene-4-sulfonic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; N,N-diethyl-1,1,1-trimethylsilanamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(95)00574-D

Reference yield:

: 187604-35-9
[(3aR,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-methanol

: 175543-73-4
(E)-3-[(3aR,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-phenyl-propenone

Guidance literature:: Multi-step reaction with 2 steps

1: DMSO, DCC

2: tetrahydrofuran

With dimethyl sulfoxide; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1016/0960-894X(95)00574-D