1,1-dimethylethyl (trans-4-{[(3-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridin-4-yl)oxy]methyl}cyclohexyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl (trans-4-{[(3-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridin-4-yl)oxy]methyl}cyclohexyl)carbamate
CAS No.:1223076-86-5
Molecular Formula:C₂₁H₂₈FN₃O₄
Molecular Weight:405.469
Hs Code.:

Synonyms:1,1-dimethylethyl (trans-4-{[(3-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridin-4-yl)oxy]methyl}cyclohexyl)carbamate

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Chemical Property of 1,1-dimethylethyl (trans-4-{[(3-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridin-4-yl)oxy]methyl}cyclohexyl)carbamate

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Technology Process of 1,1-dimethylethyl (trans-4-{[(3-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridin-4-yl)oxy]methyl}cyclohexyl)carbamate

There total 3 articles about 1,1-dimethylethyl (trans-4-{[(3-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridin-4-yl)oxy]methyl}cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1223076-85-4
7-fluoro-8-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one

: 1223579-86-9
[trans-4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)cyclohexyl]methyl ethanesulfonate

: 1223076-86-5
1,1-dimethylethyl (trans-4-{[(3-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridin-4-yl)oxy]methyl}cyclohexyl)carbamate

Guidance literature:: 7-fluoro-8-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one; With potassium carbonate; In N,N-dimethyl-formamide; at 21 - 60 ℃;

[trans-4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)cyclohexyl]methyl ethanesulfonate; In N,N-dimethyl-formamide; at 120 ℃;

Reference yield: 14.2%

: 239074-29-4
trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1223076-85-4
7-fluoro-8-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one

: 1223076-86-5
1,1-dimethylethyl (trans-4-{[(3-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridin-4-yl)oxy]methyl}cyclohexyl)carbamate

Guidance literature:: trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester; 7-fluoro-8-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one; With triphenylphosphine; In tetrahydrofuran; for 0.166667h;

With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 70 ℃;

Reference yield:

: 683269-95-6
N-[trans-4-[[(methylsulfonyl)oxy]methyl]cyclohexyl]carbamic acid tert-butyl ester

: 1223076-85-4
7-fluoro-8-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one

: 1223076-86-5
1,1-dimethylethyl (trans-4-{[(3-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridin-4-yl)oxy]methyl}cyclohexyl)carbamate

Guidance literature:: 7-fluoro-8-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 0.5h; sonication;

N-[trans-4-[[(methylsulfonyl)oxy]methyl]cyclohexyl]carbamic acid tert-butyl ester; In N,N-dimethyl-formamide; mineral oil; at 110 ℃; for 48h;