tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-hydroxyheptanoate

Base Information

Chemical Name:tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-hydroxyheptanoate
CAS No.:1227062-89-6
Molecular Formula:C₂₆H₃₇NO₃
Molecular Weight:411.585
Hs Code.:

Synonyms:tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-hydroxyheptanoate

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Chemical Property of tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-hydroxyheptanoate

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Technology Process of tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-hydroxyheptanoate

There total 5 articles about tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-hydroxyheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 117471-84-8
1,1-dimethylethyl (E)-7-hydroxyhept-2-enoate

: 1227062-89-6
tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-hydroxyheptanoate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

1,1-dimethylethyl (E)-7-hydroxyhept-2-enoate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tet.2011.09.038

Reference yield:

: 542-28-9,26354-94-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 1227062-89-6
tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-hydroxyheptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

1.3: 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.09.038

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1227062-89-6
tert-butyl (R,R)-3-[N-benzyl-N-(α-methylbenzyl)amino]-7-hydroxyheptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.09.038