3-iodo-4-hydroxymethylbenzocyclobutene tosylate

Base Information

Chemical Name:3-iodo-4-hydroxymethylbenzocyclobutene tosylate
CAS No.:77130-59-7
Molecular Formula:C₁₆H₁₅IO₃S
Molecular Weight:414.264
Hs Code.:

Synonyms:3-iodo-4-hydroxymethylbenzocyclobutene tosylate

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Chemical Property of 3-iodo-4-hydroxymethylbenzocyclobutene tosylate

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Technology Process of 3-iodo-4-hydroxymethylbenzocyclobutene tosylate

There total 4 articles about 3-iodo-4-hydroxymethylbenzocyclobutene tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 77130-55-3
3-iodo-4-hydroxymethylbenzocyclobutene

: 98-59-9
p-toluenesulfonyl chloride

: 77130-59-7
3-iodo-4-hydroxymethylbenzocyclobutene tosylate

Guidance literature:: With sodium hydroxide; In diethyl ether; at 23 ℃; for 3h;
DOI:10.1016/0040-4020(80)80220-1

Reference yield:

: 77130-56-4
2-(2-Iodo-bicyclo[4.2.0]octa-1⁽⁶⁾,2,4-trien-3-ylmethoxy)-tetrahydro-pyran

: 77130-59-7
3-iodo-4-hydroxymethylbenzocyclobutene tosylate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / p-TSA / tetrahydrofuran; aq. ethanol / 1 h / Heating

2: 74 percent / NaOH / diethyl ether / 3 h / 23 °C

With sodium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1016/0040-4020(80)80220-1

Reference yield:

: 77130-52-0
3-trimethylsilyl-4-hydroxymethylbenzocyclobutene tetrahydropyranylether

: 77130-59-7
3-iodo-4-hydroxymethylbenzocyclobutene tosylate

Guidance literature:: Multi-step reaction with 3 steps

1: ICl / CCl₄ / 0 °C

2: 93 percent / p-TSA / tetrahydrofuran; aq. ethanol / 1 h / Heating

3: 74 percent / NaOH / diethyl ether / 3 h / 23 °C

With sodium hydroxide; Iodine monochloride; toluene-4-sulfonic acid; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol;
DOI:10.1016/0040-4020(80)80220-1