2-chloro-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Base Information

• Chemical Name: 2-chloro-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide
• CAS No.: 1192021-03-6
• Molecular Formula: C₁₃H₈ClF₃N₂O₂
• Molecular Weight: 316.667
• Mol file: 1192021-03-6.mol

Synonyms:2-chloro-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Chemical Property of 2-chloro-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-chloro-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide

There total 1 articles about 2-chloro-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloroisonicotinic acid, (6313-54-8) + 2-amino-4-(trifluoromethyl)phenol (454-81-9) → 2-chloro-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide (1192021-03-6)

Guidance literature:

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 60 ℃; for 4h;

Reference yield:

2-chloro-N-[2-hydroxy-5-(trifluoromethyl)phenyl]isonicotinamide (1192021-03-6) → 2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)benzoxazole (1192019-08-1)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 - 60 ℃; for 3h;

upstream raw materials:

2-chloroisonicotinic acid,

2-amino-4-(trifluoromethyl)phenol

Downstream raw materials:

2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)benzoxazole