methyl 3-(4-(methoxycarbonyl)phenyl)-1-methylisoquinoline-6-carboxylate

Base Information

Chemical Name:methyl 3-(4-(methoxycarbonyl)phenyl)-1-methylisoquinoline-6-carboxylate
CAS No.:1619224-91-7
Molecular Formula:C₂₀H₁₇NO₄
Molecular Weight:335.359
Hs Code.:

Synonyms:methyl 3-(4-(methoxycarbonyl)phenyl)-1-methylisoquinoline-6-carboxylate

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Chemical Property of methyl 3-(4-(methoxycarbonyl)phenyl)-1-methylisoquinoline-6-carboxylate

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Technology Process of methyl 3-(4-(methoxycarbonyl)phenyl)-1-methylisoquinoline-6-carboxylate

There total 3 articles about methyl 3-(4-(methoxycarbonyl)phenyl)-1-methylisoquinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1619224-84-8
methyl 4-(1-((pivaloyloxy)imino)ethyl)benzoate

: 1619224-91-7
methyl 3-(4-(methoxycarbonyl)phenyl)-1-methylisoquinoline-6-carboxylate

Guidance literature:: With palladium diacetate; In toluene; at 150 ℃; for 36h; regioselective reaction; Sealed tube; Inert atmosphere;
DOI:10.1021/jo5010586

Reference yield:

: 3609-53-8
methyl 4-acetylbenzoate

: 1619224-91-7
methyl 3-(4-(methoxycarbonyl)phenyl)-1-methylisoquinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; potassium acetate / methanol / 0.67 h / Reflux

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: palladium diacetate / toluene / 36 h / 150 °C / Sealed tube; Inert atmosphere

With hydroxylamine hydrochloride; potassium acetate; palladium diacetate; triethylamine; In methanol; dichloromethane; toluene;
DOI:10.1021/jo5010586

Reference yield:

: 74733-31-6
methyl 4-(1-(hydroxyimino)ethyl)benzoate

: 1619224-91-7
methyl 3-(4-(methoxycarbonyl)phenyl)-1-methylisoquinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

2: palladium diacetate / toluene / 36 h / 150 °C / Sealed tube; Inert atmosphere

With palladium diacetate; triethylamine; In dichloromethane; toluene;
DOI:10.1021/jo5010586