2-(2-(4-((R)-5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)hexahydrocyclopenta[c]pyrrol-5(1H)-ylidene)acetonitrile

Base Information

Chemical Name:2-(2-(4-((R)-5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)hexahydrocyclopenta[c]pyrrol-5(1H)-ylidene)acetonitrile
CAS No.:1395323-01-9
Molecular Formula:C₂₁H₂₁FN₆O₂
Molecular Weight:408.435
Hs Code.:

Synonyms:2-(2-(4-((R)-5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)hexahydrocyclopenta[c]pyrrol-5(1H)-ylidene)acetonitrile

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Chemical Property of 2-(2-(4-((R)-5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)hexahydrocyclopenta[c]pyrrol-5(1H)-ylidene)acetonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-(4-((R)-5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)hexahydrocyclopenta[c]pyrrol-5(1H)-ylidene)acetonitrile

There total 10 articles about 2-(2-(4-((R)-5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)hexahydrocyclopenta[c]pyrrol-5(1H)-ylidene)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1395323-01-9
2-(2-(4-((R)-5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)hexahydrocyclopenta[c]pyrrol-5(1H)-ylidene)acetonitrile

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 1h;

In tetrahydrofuran; at -78 - 20 ℃; for 3h;

Reference yield: 80.0%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 1395322-95-8
(5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-oxohexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one

: 1395323-01-9
2-(2-(4-((R)-5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)hexahydrocyclopenta[c]pyrrol-5(1H)-ylidene)acetonitrile

Guidance literature:: diethyl 1-cyanomethylphosphonate; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 1h;

(5R)-5-((1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-(5-oxohexahydrocyclopenta[c]pyrrol-2(1H)-yl)phenyl)oxazolidin-2-one; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1111/j.1747-0285.2012.01404.x

Reference yield:

: 1395322-86-7
2-(2-fluoro-4-nitrophenyl)-5-oxohexahydrocyclopenta[c]pyrrole

: 1395323-01-9
2-(2-(4-((R)-5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)hexahydrocyclopenta[c]pyrrol-5(1H)-ylidene)acetonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / water; benzene / 3 h / Reflux; Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h / 20 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

4.2: 12 h / -78 - 20 °C

5.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C

7.1: 48 h / Reflux

8.1: toluene-4-sulfonic acid / water; acetone / 6 h / Reflux

9.1: potassium tert-butylate / tetrahydrofuran / 1 h / -78 °C

9.2: -78 - 20 °C

With n-butyllithium; sodium azide; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1111/j.1747-0285.2012.01404.x