2-tert-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester
CAS No.:701261-96-3
Molecular Formula:C₄₈H₆₈N₆O₁₁
Molecular Weight:905.102
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4<i>H</i>-pyrimidine-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:2-tert-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 2-tert-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester

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Technology Process of 2-tert-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester

There total 21 articles about 2-tert-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 828-01-3,7326-19-4,20312-36-1,156-05-8
D-phenyllactic acid

: 701261-96-3
2-tert-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: diethyl ether

2: 0.460 g / i-Pr₂NEt / CH₂Cl₂

3: 100 percent / aq. LiOH / tetrahydrofuran / 1 h

4: 89 percent / EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

5: 100 percent / H₂ / Pd/C / methanol; ethyl acetate / 760 Torr

6: 0.150 g / EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

7: NaOMe / methanol / 4 h

8: 0.120 g / i-Pr₂NEt / CH₂Cl₂

9: aq. LiOH / tetrahydrofuran / 7 h

10: i-Pr₃NEt; EDC; HOBt / CH₂Cl₂ / 0 - 20 °C

With lithium hydroxide; hydrogen; sodium methylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/ja030669g

Reference yield:

: 27000-00-6
methyl 2-hydroxy-3-phenylpropionate

: 701261-96-3
2-tert-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 0.460 g / i-Pr₂NEt / CH₂Cl₂

2: 100 percent / aq. LiOH / tetrahydrofuran / 1 h

3: 89 percent / EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

4: 100 percent / H₂ / Pd/C / methanol; ethyl acetate / 760 Torr

5: 0.150 g / EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

6: NaOMe / methanol / 4 h

7: 0.120 g / i-Pr₂NEt / CH₂Cl₂

8: aq. LiOH / tetrahydrofuran / 7 h

9: i-Pr₃NEt; EDC; HOBt / CH₂Cl₂ / 0 - 20 °C

With lithium hydroxide; hydrogen; sodium methylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/ja030669g

Reference yield:

: 701261-90-7
methyl (R)-2-(methoxymethoxy)-3-phenylpropanoate

: 701261-96-3
2-tert-butoxycarbonylamino-5-[3-({6-methoxymethoxy-1-[2-(2-methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionyl]-octahydro-indole-2-carbonyl}-amino)-propylidene]-5,6-dihydro-4H-pyrimidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / aq. LiOH / tetrahydrofuran / 1 h

2: 89 percent / EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

3: 100 percent / H₂ / Pd/C / methanol; ethyl acetate / 760 Torr

4: 0.150 g / EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

5: NaOMe / methanol / 4 h

6: 0.120 g / i-Pr₂NEt / CH₂Cl₂

7: aq. LiOH / tetrahydrofuran / 7 h

8: i-Pr₃NEt; EDC; HOBt / CH₂Cl₂ / 0 - 20 °C

With lithium hydroxide; hydrogen; sodium methylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/ja030669g