(-)-(1S,2S)-N-(2-methoxymethylpyrrolidin-1-yl)-N-(1-propylbut-3-enyl)acrylamide

Base Information

Chemical Name:(-)-(1S,2S)-N-(2-methoxymethylpyrrolidin-1-yl)-N-(1-propylbut-3-enyl)acrylamide
CAS No.:944128-08-9
Molecular Formula:C₁₆H₂₈N₂O₂
Molecular Weight:280.411
Hs Code.:

Synonyms:(-)-(1S,2S)-N-(2-methoxymethylpyrrolidin-1-yl)-N-(1-propylbut-3-enyl)acrylamide

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Chemical Property of (-)-(1S,2S)-N-(2-methoxymethylpyrrolidin-1-yl)-N-(1-propylbut-3-enyl)acrylamide

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Technology Process of (-)-(1S,2S)-N-(2-methoxymethylpyrrolidin-1-yl)-N-(1-propylbut-3-enyl)acrylamide

There total 1 articles about (-)-(1S,2S)-N-(2-methoxymethylpyrrolidin-1-yl)-N-(1-propylbut-3-enyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 944128-08-9
(-)-(1S,2S)-N-(2-methoxymethylpyrrolidin-1-yl)-N-(1-propylbut-3-enyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / MgSO₄ / CH₂Cl₂ / 12 h / 20 °C

2.1: PhLi / diethyl ether; dibutyl ether / 0.5 h / 20 °C

2.2: diethyl ether; dibutyl ether / -78 - 20 °C

2.3: 52 percent / diethyl ether; dibutyl ether / -78 - 20 °C

With magnesium sulfate; phenyllithium; In diethyl ether; dichloromethane; dibutyl ether;
DOI:10.1021/ol070757w

Reference yield:

: 944128-08-9
(-)-(1S,2S)-N-(2-methoxymethylpyrrolidin-1-yl)-N-(1-propylbut-3-enyl)acrylamide

: 555-92-0,15991-59-0,51541-42-5,88057-03-8
(S)-coniine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / second generation Grubbs catalyst / CH₂Cl₂ / 24 h / 20 °C

2: 97 percent / H₂ / Pd/C / ethanol / 12 h / 20 °C / 760.05 Torr

3: BH₃*THF / tetrahydrofuran / 24 h / Heating

With borane-THF; hydrogen; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol070757w