ethyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3-pyridinepropanoate

Base Information

• Chemical Name: ethyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3-pyridinepropanoate
• CAS No.: 853181-51-8
• Molecular Formula: C₂₁H₂₅FN₂O₄
• Molecular Weight: 388.439

Synonyms:ethyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3-pyridinepropanoate

Chemical Property of ethyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3-pyridinepropanoate

Chemical Property:

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Technology Process of ethyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3-pyridinepropanoate

There total 1 articles about ethyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3-pyridinepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 6-amino-5-(3-ethoxy-3-oxopropenyl)-4-(4-fluorophenyl)-2-isopropylnicotinate → ethyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3-pyridinepropanoate (853181-51-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 23h; under 3863.02 Torr; Product distribution / selectivity;

Reference yield: 92.0%

ethyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3-pyridinepropanoate (853181-51-8) → methyl 4-(4-fluorophenyl)-2-isopropyl-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate (853181-52-9)

Guidance literature:

toluene-4-sulfonic acid; In toluene; at 100 - 110 ℃; for 3 - 3.5h; Product distribution / selectivity;

Reference yield:

ethyl 2-amino-4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3-pyridinepropanoate (853181-51-8) → C19H23FN2O3

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 0 - 5 ℃; for 1.25h;

Downstream raw materials:

methyl 4-(4-fluorophenyl)-2-isopropyl-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridine-3-carboxylate

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