4-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoyl}-pyrrolidine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Name:4-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoyl}-pyrrolidine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:485834-26-2
Molecular Formula:C₃₁H₄₃N₅O₆
Molecular Weight:581.712
Hs Code.:

Synonyms:4-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoyl}-pyrrolidine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoyl}-pyrrolidine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoyl}-pyrrolidine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

There total 7 articles about 4-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoyl}-pyrrolidine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 473797-81-8
isophthalic acid L-proline L-prolyl-pyrrolidine amide

: 485834-26-2
4-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoyl}-pyrrolidine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: isophthalic acid L-proline L-prolyl-pyrrolidine amide; With pivaloyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 1h;

1-t-Butoxycarbonylpiperazine; With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm030811o

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 485834-26-2
4-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoyl}-pyrrolidine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 54 percent / CH₂Cl₂ / 20 °C

2.1: pivaloyl chloride; triethylamine / CH₂Cl₂ / 1 h / 0 °C

2.2: triethylamine / CH₂Cl₂ / 20 °C

With pivaloyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm030811o

Reference yield:

: 144243-44-7,155251-70-0
tert-butyl (S)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate

: 485834-26-2
4-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-benzoyl}-pyrrolidine-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: HCl / ethyl acetate / 0.5 h / 20 °C

2.1: pivaloyl chloride; triethylamine / CH₂Cl₂ / 1 h / 0 °C

2.2: triethylamine / CH₂Cl₂ / 20 °C

3.1: 5.1 g / aq. LiOH / methanol / 20 °C

4.1: pivaloyl chloride; triethylamine / CH₂Cl₂ / 1 h / 0 °C

4.2: 61 percent / triethylamine / CH₂Cl₂ / 20 °C

5.1: 81 percent / aq. LiOH / methanol / 20 °C

6.1: pivaloyl chloride; triethylamine / CH₂Cl₂ / 1 h / 0 °C

6.2: triethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; lithium hydroxide; pivaloyl chloride; triethylamine; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm030811o