2-phenylpyrazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-phenylpyrazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester
• CAS No.: 340322-65-8
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.299
• Mol file: 340322-65-8.mol

Synonyms:2-phenylpyrazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester

Chemical Property of 2-phenylpyrazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 2-phenylpyrazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester

There total 1 articles about 2-phenylpyrazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C10H7ClN2O (1024611-61-7) + ethyl (E)-4-bromo-3-methyl-2-butenoate (51318-62-8) → 2-phenylpyrazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester (340322-65-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.3987/COM-08-11510

Reference yield: 91.0%

2-phenylpyrazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester (340322-65-8) → 2-phenylpyrazolo[1,5-a]pyridine-5-carboxylic acid

Guidance literature:

With sodium hydroxide; In ethanol; water; for 4h; Reflux;

DOI:10.1039/C8RA06191B

Reference yield: 89.3%

2-phenylpyrazolo[1,5-a]pyridine-5-carboxylic acid ethyl ester (340322-65-8) → 2-phenyl-5-hydroxymethylpyrazolo[1,5-a]pyridine

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 80 ℃; for 10h;

upstream raw materials:

C₁₀H₇ClN₂O

ethyl (E)-4-bromo-3-methyl-2-butenoate

Downstream raw materials:

2-phenylpyrazolo[1,5-a]pyridine-5-carbohydrazide

2-phenyl-5-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrazolo[1,5-a]pyridine