(E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-fluoro-phenyl)-acrylamide

Base Information

Chemical Name:(E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-fluoro-phenyl)-acrylamide
CAS No.:1026960-58-6
Molecular Formula:C₁₉H₂₃FN₄O₃
Molecular Weight:374.415
Hs Code.:

Synonyms:(E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-fluoro-phenyl)-acrylamide

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Chemical Property of (E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-fluoro-phenyl)-acrylamide

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Technology Process of (E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-fluoro-phenyl)-acrylamide

There total 2 articles about (E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-fluoro-phenyl)-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-amino-6-nitroso-1,3-dipropyluracil

: 1026960-58-6
(E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-fluoro-phenyl)-acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / dimethylformamide / 2068.6 Torr

2: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(N,N-dimethylamino)pyridine, imidazole / dimethylformamide / 3 h / Ambient temperature

With 1H-imidazole; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1021/jm00062a005

Reference yield:

: 81250-34-2
1,3-dipropyl-5,6-diaminouracil

: 20595-30-6
3-Fluorocinnamic acid

: 1026960-58-6
(E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-fluoro-phenyl)-acrylamide

Guidance literature:: With 1H-imidazole; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1021/jm00062a005