2(S)-N-[(E)-2(3-methoxyphenyl)ethanyl]-1-tert-butoxycarbonyl-2-pyrrolinecarboxamide

Base Information

Chemical Name:2(S)-N-[(E)-2(3-methoxyphenyl)ethanyl]-1-tert-butoxycarbonyl-2-pyrrolinecarboxamide
CAS No.:863330-79-4
Molecular Formula:C₁₉H₂₆N₂O₄
Molecular Weight:346.426
Hs Code.:

Synonyms:2(S)-N-[(E)-2(3-methoxyphenyl)ethanyl]-1-tert-butoxycarbonyl-2-pyrrolinecarboxamide

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Chemical Property of 2(S)-N-[(E)-2(3-methoxyphenyl)ethanyl]-1-tert-butoxycarbonyl-2-pyrrolinecarboxamide

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Technology Process of 2(S)-N-[(E)-2(3-methoxyphenyl)ethanyl]-1-tert-butoxycarbonyl-2-pyrrolinecarboxamide

There total 6 articles about 2(S)-N-[(E)-2(3-methoxyphenyl)ethanyl]-1-tert-butoxycarbonyl-2-pyrrolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2-benzenesulfinyl-2-(3-methoxy-phenyl)-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 863330-79-4
2(S)-N-[(E)-2(3-methoxyphenyl)ethanyl]-1-tert-butoxycarbonyl-2-pyrrolinecarboxamide

Guidance literature:: With sodium carbonate; In toluene; for 2h; Heating;
DOI:10.3390/10010295

Reference yield:

: 3179-09-7,55446-68-9
(E)-1-methoxy-3-(2-nitrovinyl)benzene

: 863330-79-4
2(S)-N-[(E)-2(3-methoxyphenyl)ethanyl]-1-tert-butoxycarbonyl-2-pyrrolinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / N-isopropylcyclohexylamine / CH₂Cl₂ / 1 h / 20 °C

2: 45 percent / acetic acid; Zn; HCL / 20 °C

3: 20 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; 4-N,N-dimethylaminopyridine / tetrahydrofuran / 24 h

4: sodium periodate / methanol; H₂O / 1.5 h / Heating

5: 0.30 g / sodium carbonate / toluene / 2 h / Heating

With hydrogenchloride; dmap; sodium periodate; N-cyclohexylisopropylamine; sodium carbonate; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 1: Michael addition;
DOI:10.3390/10010295

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 863330-79-4
2(S)-N-[(E)-2(3-methoxyphenyl)ethanyl]-1-tert-butoxycarbonyl-2-pyrrolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / glacial acetic acid; ammonium acetate / 1 h / Heating

2: 90 percent / N-isopropylcyclohexylamine / CH₂Cl₂ / 1 h / 20 °C

3: 45 percent / acetic acid; Zn; HCL / 20 °C

4: 20 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; 4-N,N-dimethylaminopyridine / tetrahydrofuran / 24 h

5: sodium periodate / methanol; H₂O / 1.5 h / Heating

6: 0.30 g / sodium carbonate / toluene / 2 h / Heating

With ammonium acetate; hydrogenchloride; dmap; sodium periodate; N-cyclohexylisopropylamine; sodium carbonate; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 2: Michael addition;
DOI:10.3390/10010295