1-(4-chloro-3-fluorophenethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Name:1-(4-chloro-3-fluorophenethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453848-23-1
Molecular Formula:C₂₂H₂₂ClFN₄O₂
Molecular Weight:428.894
Hs Code.:

Synonyms:1-(4-chloro-3-fluorophenethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of 1-(4-chloro-3-fluorophenethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of 1-(4-chloro-3-fluorophenethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

There total 6 articles about 1-(4-chloro-3-fluorophenethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1453853-63-8
4-chloro-3-fluorophenethyl methanesulfonate

: 1453851-89-2
4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-pyridin-2(1H)-one

: 1453848-23-1
1-(4-chloro-3-fluorophenethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: 4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-pyridin-2(1H)-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h; Inert atmosphere;

4-chloro-3-fluorophenethyl methanesulfonate; In N,N-dimethyl-formamide; mineral oil;

Reference yield: 17.0%

: 1453851-89-2
4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-pyridin-2(1H)-one

: C₉H₁₀ClFO₂S

: 1453848-23-1
1-(4-chloro-3-fluorophenethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 25 ℃; Inert atmosphere;
DOI:10.1021/jm501921k

Reference yield:

: 401815-98-3
2-fluoropyridin-4-ylboronic acid

: 1453848-23-1
1-(4-chloro-3-fluorophenethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 3 h / 80 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; iso-butanol / 100 °C / Microwave irradiation; Sealed tube

3: hydrogenchloride / water / Reflux

4: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; iso-butanol; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 1: |Suzuki Coupling;