Technology Process of (5aS,11aR)-5-benzyl-2-bromo-10-methyl-10,11-dihydro-5H-5a,11a-butanocyclopenta[1,2-b:3,4-b']diindole
There total 3 articles about (5aS,11aR)-5-benzyl-2-bromo-10-methyl-10,11-dihydro-5H-5a,11a-butanocyclopenta[1,2-b:3,4-b']diindole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin;
In
toluene;
at 45 ℃;
for 36h;
enantioselective reaction;
DOI:10.1002/anie.201301618
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide
2: hydrogen; palladium 10% on activated carbon
3: (11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin / toluene / 36 h / 45 °C
With
palladium 10% on activated carbon; (11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin; hydrogen; sodium hydroxide;
In
toluene;
3: |Fischer Indole Synthesis;
DOI:10.1002/anie.201301618
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen; palladium 10% on activated carbon
2: (11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin / toluene / 36 h / 45 °C
With
palladium 10% on activated carbon; (11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-bis[2,4,6-triisopropylphenyl]-5-oxide-diindeno[7,1-de:1',7’-fg][1,3,2]dioxaphosphocin; hydrogen;
In
toluene;
2: |Fischer Indole Synthesis;
DOI:10.1002/anie.201301618
