3-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethoxy]-benzoic acid methyl ester

Base Information

Chemical Name:3-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethoxy]-benzoic acid methyl ester
CAS No.:165404-93-3
Molecular Formula:C₂₀H₂₈O₄S₂Si
Molecular Weight:424.657
Hs Code.:

Synonyms:3-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethoxy]-benzoic acid methyl ester

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Chemical Property of 3-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethoxy]-benzoic acid methyl ester

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Technology Process of 3-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethoxy]-benzoic acid methyl ester

There total 4 articles about 3-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethoxy]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.3%

: 19438-10-9
methyl 3-hydroxybenzoate

: 165404-83-1
3-[(tert-butyldimethylsilyloxy)methyl]-6-(hydroxymethyl)-1,2-dithiin

: 165404-93-3
3-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethoxy]-benzoic acid methyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 5 ℃; for 3h;
DOI:10.1021/jm00014a016

Reference yield:

: 2,5-bis<(2-cyanoethyl)thio>-2,4-hexadiene-1,6-diol

: 165404-93-3
3-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethoxy]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 49.3 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

2: 1.) t-BuOK, 2.) aq. K₃FeCN₆ / 1.) eter, 11 min, 2.) eter, 12 min

3: 60.3 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 5 °C

With 1H-imidazole; potassium tert-butylate; triphenylphosphine; potassium hexacyanoferrate(III); diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00014a016

Reference yield:

: 1-<(tert-butyldimethylsilyl)oxy>-2,5-bis<(2-cyanoethyl)thio>-2,4-hexadien-6-ol

: 165404-93-3
3-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethoxy]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) t-BuOK, 2.) aq. K₃FeCN₆ / 1.) eter, 11 min, 2.) eter, 12 min

2: 60.3 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 5 °C

With potassium tert-butylate; triphenylphosphine; potassium hexacyanoferrate(III); diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/jm00014a016