Technology Process of 2H-Pyran-2-one,6-[(1E,3E,5E)-3,5-dimethyl- 6-phenyl-1,3,5-hexatrienyl]-4-methoxy-5- methyl-
There total 8 articles about 2H-Pyran-2-one,6-[(1E,3E,5E)-3,5-dimethyl- 6-phenyl-1,3,5-hexatrienyl]-4-methoxy-5- methyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2E,4E)-2,4-dimethyl-5-phenylpenta-2,4-dienal;
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
4-methoxy-5.6-dimethyl-2H-pyran-2-one;
In
tetrahydrofuran;
at -78 - 0 ℃;
for 1h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1016/j.tetlet.2021.153574
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 2 h / Reflux; Inert atmosphere
2.1: potassium carbonate / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 - 0 °C / Inert atmosphere
With
potassium hexamethylsilazane; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; dimethyl sulfoxide; toluene;
3.1: |Aldol Condensation / 3.2: |Aldol Condensation;
DOI:10.1016/j.tetlet.2021.153574
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 °C / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 2 h / Reflux; Inert atmosphere
3.1: potassium carbonate / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere
3.2: 2 h / 20 °C / Inert atmosphere
4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
4.2: 1 h / -78 - 0 °C / Inert atmosphere
With
n-butyllithium; potassium hexamethylsilazane; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; hexane; dimethyl sulfoxide; toluene;
4.1: |Aldol Condensation / 4.2: |Aldol Condensation;
DOI:10.1016/j.tetlet.2021.153574