tert-butyl 4-chloro-2-(7-chloro-1,1,1-trifluoro-2-hydroxyhept-3-yn-2-yl)phenylcarbamate

Base Information

• Chemical Name: tert-butyl 4-chloro-2-(7-chloro-1,1,1-trifluoro-2-hydroxyhept-3-yn-2-yl)phenylcarbamate
• CAS No.: 202721-01-5
• Molecular Formula: C₁₈H₂₀Cl₂F₃NO₃
• Molecular Weight: 426.263

Synonyms:tert-butyl 4-chloro-2-(7-chloro-1,1,1-trifluoro-2-hydroxyhept-3-yn-2-yl)phenylcarbamate

Chemical Property of tert-butyl 4-chloro-2-(7-chloro-1,1,1-trifluoro-2-hydroxyhept-3-yn-2-yl)phenylcarbamate

Chemical Property:

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Technology Process of tert-butyl 4-chloro-2-(7-chloro-1,1,1-trifluoro-2-hydroxyhept-3-yn-2-yl)phenylcarbamate

There total 3 articles about tert-butyl 4-chloro-2-(7-chloro-1,1,1-trifluoro-2-hydroxyhept-3-yn-2-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

7-chloro-1,1,1-trifluoro-hept-3-yn-2-one (1132911-31-9) + N-(t-butoxycarbonyl)-4-chloroaniline (18437-66-6) → tert-butyl 4-chloro-2-(7-chloro-1,1,1-trifluoro-2-hydroxyhept-3-yn-2-yl)phenylcarbamate (202721-01-5)

Guidance literature:

N-(t-butoxycarbonyl)-4-chloroaniline; With tert.-butyl lithium; In diethyl ether; pentane; at -15 ℃; for 2h; Inert atmosphere;

7-chloro-1,1,1-trifluoro-hept-3-yn-2-one; In diethyl ether; pentane; at -70 - -60 ℃; for 1h; Inert atmosphere;

Reference yield: 59.0%

tert-butyl-4-chloro-2-(2,2,2-trifluoroacetyl)phenyl carbamate (201218-07-7) + 1-chloro-4-pentyne (14267-92-6) → tert-butyl 4-chloro-2-(7-chloro-1,1,1-trifluoro-2-hydroxyhept-3-yn-2-yl)phenylcarbamate (202721-01-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

Reference yield: 59.0%

→ tert-butyl 4-chloro-2-(7-chloro-1,1,1-trifluoro-2-hydroxyhept-3-yn-2-yl)phenylcarbamate (202721-01-5)

Guidance literature:

upstream raw materials:

tert-butyl-4-chloro-2-(2,2,2-trifluoroacetyl)phenyl carbamate

1-chloro-4-pentyne

7-chloro-1,1,1-trifluoro-hept-3-yn-2-one

N-(t-butoxycarbonyl)-4-chloroaniline

Downstream raw materials:

tert-butyl 4-chloro-2-(4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenylcarbamate

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