(S)-4-benzyl-3-((2R,3R)-5-(4,5-diphenyloxazol-2-yl)-2-methyl-3-(triethylsilyloxy)pentanoyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-benzyl-3-((2R,3R)-5-(4,5-diphenyloxazol-2-yl)-2-methyl-3-(triethylsilyloxy)pentanoyl)oxazolidin-2-one
CAS No.:929882-86-0
Molecular Formula:C₃₇H₄₄N₂O₅Si
Molecular Weight:624.852
Hs Code.:

Synonyms:(S)-4-benzyl-3-((2R,3R)-5-(4,5-diphenyloxazol-2-yl)-2-methyl-3-(triethylsilyloxy)pentanoyl)oxazolidin-2-one

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Chemical Property of (S)-4-benzyl-3-((2R,3R)-5-(4,5-diphenyloxazol-2-yl)-2-methyl-3-(triethylsilyloxy)pentanoyl)oxazolidin-2-one

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Technology Process of (S)-4-benzyl-3-((2R,3R)-5-(4,5-diphenyloxazol-2-yl)-2-methyl-3-(triethylsilyloxy)pentanoyl)oxazolidin-2-one

There total 4 articles about (S)-4-benzyl-3-((2R,3R)-5-(4,5-diphenyloxazol-2-yl)-2-methyl-3-(triethylsilyloxy)pentanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 917988-96-6
(S)-4-benzyl-3-((2R,3R)-5-(4,5-diphenyloxazol-2-yl)-3-hydroxy-2-methylpentanoyl)oxazolidin-2-one

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 929882-86-0
(S)-4-benzyl-3-((2R,3R)-5-(4,5-diphenyloxazol-2-yl)-2-methyl-3-(triethylsilyloxy)pentanoyl)oxazolidin-2-one

Guidance literature:: With 2,6-dimethylpyridine; In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.416667h;
DOI:10.1002/anie.200603654

Reference yield:

: 917988-94-4
(E)-3-(4,5-diphenyloxazol-2-yl)acrylaldehyde

: 929882-86-0
(S)-4-benzyl-3-((2R,3R)-5-(4,5-diphenyloxazol-2-yl)-2-methyl-3-(triethylsilyloxy)pentanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / magnesium chloride; trimethylsilylchloride; triethylamine / ethyl acetate / 1.5 h / 77 °C

2: 100 percent / hydrogen / Pd/C / ethyl acetate / 12 h / 20 °C

3: 90 percent / 2,6-lutidine / CH₂Cl₂; tetrahydrofuran / 0.42 h / 0 °C

With 2,6-dimethylpyridine; chloro-trimethyl-silane; hydrogen; triethylamine; magnesium chloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1002/anie.200603654

Reference yield:

: 917988-95-5
(S)-4-benzyl-3-((2R,3R,E)-5-(4,5-diphenyloxazol-2-yl)-3-hydroxy-2-methylpent-4-enoyl)oxazolidin-2-one

: 929882-86-0
(S)-4-benzyl-3-((2R,3R)-5-(4,5-diphenyloxazol-2-yl)-2-methyl-3-(triethylsilyloxy)pentanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / hydrogen / Pd/C / ethyl acetate / 12 h / 20 °C

2: 90 percent / 2,6-lutidine / CH₂Cl₂; tetrahydrofuran / 0.42 h / 0 °C

With 2,6-dimethylpyridine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1002/anie.200603654