(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenyl-4-pentenoate

Base Information

Chemical Name:(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenyl-4-pentenoate
CAS No.:154520-19-1
Molecular Formula:C₃₄H₄₈N₂O₄S
Molecular Weight:580.832
Hs Code.:

Synonyms:(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenyl-4-pentenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenyl-4-pentenoate

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Technology Process of (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenyl-4-pentenoate

There total 3 articles about (2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenyl-4-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 106-95-6
allyl bromide

: (2RS)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-phenyl-2-cyanoacetate

: 171038-15-6
(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenyl-4-pentenoate

: 154520-19-1
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenyl-4-pentenoate

Guidance literature:: With lithium diisopropyl amide; Yield given; 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d;
DOI:10.1021/jo00088a034

Reference yield:

: 30698-30-7
methyl 2-cyano-2-phenylacetate

: 154520-19-1
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenyl-4-pentenoate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / AlMe₃ / toluene; hexane / 1.) r.t., 30 min, 2.) 80 deg C, 8 h

2: 83 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d

With trimethylaluminum; lithium diisopropyl amide; In hexane; toluene;
DOI:10.1021/jo00088a034

Reference yield:

: 96303-88-7
(-)-10-dicyclohexylsulfamoyl-D-isoborneol

: 154520-19-1
(2S)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-phenyl-4-pentenoate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / AlMe₃ / toluene; hexane / 1.) r.t., 30 min, 2.) 80 deg C, 8 h

2: 83 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d

With trimethylaluminum; lithium diisopropyl amide; In hexane; toluene;
DOI:10.1021/jo00088a034