(2S)-3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoic acid

Base Information

Chemical Name:(2S)-3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoic acid
CAS No.:100431-38-7
Molecular Formula:C₁₃H₁₇NO₃S
Molecular Weight:267.349
Hs Code.:

Synonyms:(2S)-3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoic acid

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Chemical Property of (2S)-3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoic acid

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Technology Process of (2S)-3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoic acid

There total 4 articles about (2S)-3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100431-36-5
(2RS)-ethyl 3-<<(1R)-1-<(acetylthio)methyl>-2-phenylethyl>amino>-2-methyl-3-oxopropanoate

: 100431-38-7
(2S)-3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoic acid

: 100431-37-6
(2R)-3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoic acid

Guidance literature:: With sodium hydroxide; In methanol; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm00155a027

Reference yield:

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 100431-38-7
(2S)-3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / SOCl₂ / dimethylformamide / 2 h / 120 °C

2: 85 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CHCl₃; tetrahydrofuran / Ambient temperature

3: 78 percent / acetonitrile / 1 h / 85 °C

4: 1N aq. NaOH / methanol / 2 h / 0 - 20 °C

With sodium hydroxide; thionyl chloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00155a027

Reference yield:

: 100431-34-3
(2RS)-ethyl-3-<<(1R)-1-(chloromethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoete

: 100431-38-7
(2S)-3-<<(1R)-1-(mercaptomethyl)-2-phenylethyl>amino>-2-methyl-3-oxopropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / acetonitrile / 1 h / 85 °C

2: 1N aq. NaOH / methanol / 2 h / 0 - 20 °C

With sodium hydroxide; In methanol; acetonitrile;
DOI:10.1021/jm00155a027