methyl (E)-3-[(2'R,3'R,4'R,5'S)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenoate

Base Information

Chemical Name:methyl (E)-3-[(2'R,3'R,4'R,5'S)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenoate
CAS No.:909192-16-1
Molecular Formula:C₄₇H₅₁NO₇Si
Molecular Weight:770.01
Hs Code.:

Synonyms:methyl (E)-3-[(2'R,3'R,4'R,5'S)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenoate

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Chemical Property of methyl (E)-3-[(2'R,3'R,4'R,5'S)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenoate

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Technology Process of methyl (E)-3-[(2'R,3'R,4'R,5'S)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenoate

There total 4 articles about methyl (E)-3-[(2'R,3'R,4'R,5'S)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R,4R,5R)-3,4-dibenzyloxy-2'-O-tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine

: 909192-16-1
methyl (E)-3-[(2'R,3'R,4'R,5'S)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 25 percent / K₂CO₃ / acetone / 6 h / 20 °C

2: molecular sieves 4 Angstroem; N-oxide-N-methylmorpholine; tetra-n-propylammonium perruthenate / CH₂Cl₂ / 1 h / 20 °C

3: 93 percent / CH₂Cl₂ / 48 h / 20 °C

With tetrapropylammonium perruthennate; 4 A molecular sieve; potassium carbonate; 4-methylmorpholine N-oxide; In dichloromethane; acetone;
DOI:10.1080/07328300600735181

Reference yield:

: 909192-15-0
(2S,3R,4R,5R)-3,4-dibenzyloxy-N-benzyloxycarbonyl-2'-O-tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine

: 909192-16-1
methyl (E)-3-[(2'R,3'R,4'R,5'S)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenoate

Guidance literature:: Multi-step reaction with 2 steps

1: molecular sieves 4 Angstroem; N-oxide-N-methylmorpholine; tetra-n-propylammonium perruthenate / CH₂Cl₂ / 1 h / 20 °C

2: 93 percent / CH₂Cl₂ / 48 h / 20 °C

With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In dichloromethane;
DOI:10.1080/07328300600735181

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 909192-16-1
methyl (E)-3-[(2'R,3'R,4'R,5'S)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 25 percent / K₂CO₃ / acetone / 6 h / 20 °C

2: molecular sieves 4 Angstroem; N-oxide-N-methylmorpholine; tetra-n-propylammonium perruthenate / CH₂Cl₂ / 1 h / 20 °C

3: 93 percent / CH₂Cl₂ / 48 h / 20 °C

With tetrapropylammonium perruthennate; 4 A molecular sieve; potassium carbonate; 4-methylmorpholine N-oxide; In dichloromethane; acetone;
DOI:10.1080/07328300600735181